Abstract

Worldwide, Coronary Artery Disease (CAD) is one of the leading causes of death. Patients from the Indian subcontinent present relatively early and may have more extensive CAD.  Various Conventional and Novel risk factors for CAD have been studied. In this study apart from the Conventional risk factors, we assessed the Novel risk factors like Hyperhomocysteinaemia, Lipoprotein a (Lpa), Apolipoprotein B (Apo B), Apolipoprotein A₁ (Apo A₁) and Apolipoprotein B/A ratio in both the Elderly (>45 years) & Young (≤45years) groups and correlated their values with the SYNTAX Score to find out if there was any correlation between the levels of the Novel risk factors and the SYNTAX score. We found that the Homocysteine levels in young patients correlated linearly with their respective Syntax scores with a highly significant ‘p’ value of 0.001355. This was however not so in the elderly group. It was also derived from this study that serum Homocysteine levels in young coronary artery disease patients are 83.33% sensitive, 91.67% specific and 86.67% accurate in predicting complexity of coronary lesions and thus the aggressiveness of the disease in terms of their Syntax scores.