Title: Clinical Study of Thrombocytopenia
Authors: Dr Shankarappa R S, Dr Naveen K
DOI: https://dx.doi.org/10.18535/jmscr/v8i1.54
Abstract
Background: Thrombocytopenia is the commonest platelet abnormality encountered in clinical practice with variable clinical manifestations. Clinicians may encounter many cases of thrombocytopenia which requires systematic evaluation to find out the underlying cause.
Methods: It is a prospective study conducted in Department of General Medicine, Shridevi institute of medical sciences and research hospital, Tumakuru, for a period of one year from November 2018 to October 2019. There are 100 patients satisfying the criteria of thrombocytopenia who are included in the study. Further evaluation of these cases based on clinical history, clinical signs, detailed physical and systemic examination, laboratory investigations and underlying etiology were carried out.
Result: Out of 100 patients with thrombocytopenia, 60% were Males. The highest incidence in the age group of 15-30 years constituting 42%. Fever is the most common presenting complaint constituting 59% followed by Pain abdomen and vomiting in 23%.Out of the 100 patients in the study,14% had mild,54% had moderate and 32% had severe thrombocytopenia. The commonest investigation abnormalities are 38% positive Dengue serology, 19% pancytopenia,35% leucopenia,24% anaemia,16% altered renal function,17% altered hepatic function and 23% significant abdominal sonographic findings. The commonest cause of thrombocytopenia are infections like Dengue in 38% of cases and septicaemia in 20% of cases followed by Chronic liver disease in 8% cases.
Conclusion: The most common cause of thrombocytopenia in the study are infections like Dengue fever and septicaemia followed by Chronic liver disease. Thrombocytopenia requires detailed systematic evaluation to find out the underlying cause and it resolves spontaneously on treating the cause.
Keywords: Symptoms, Signs, Etiology, Thrombocytopenia.
