Abstract

Objective: In this study our main goal is to evaluate the current status of treatment among migraine patients in Bangladesh.

Methods: This randomized single blind cross over clinical trial was conducted at Department of Pharmacology, Dhaka medical college, Dhaka from July 2015 to June 2016. During the study, adult 64 migraine sufferers (without aura) attending in the Out Patient Department of neurology (Headache clinic), Dhaka Medical College Hospital, Dhaka. All data were recorded systematically in data collection form. One half of the samples were randomly allocated for group A and the other half to group B. Group A: 32 patients will be allocated for the prophylaxis of  propranolol. Group B: 32 patients will be allocated for the prophylaxis of flunarizine.

Results: During the study, most common presenting complaints of group A were nausea (81.25%), bothered by light/noise (68.75%), vomiting (56.25%), sparkling, flushing or colored light (37.5), and numbness/ tingling (25%) and in group B were nausea (87.5%), vomiting (65.62%), bothered by light/noise (56.25%), and spakling, flushing or colored lights (43.75%).group A were nausea (81.25%), bothered by light/noise (68.75%), vomiting (56.25%), sparkling, flushing or colored light (37.5), and numbness/tingling (25%) and in group B were nausea (87.5%), vomiting (65.62%), bothered by light/noise (56.25%), and spakling, flushing or colored lights (43.75%).Where prior to second phase of treatment, four weeks were given for wash out for previous medication. Then crossover of treatment was done, i.e group A was assigned flunarizine and group B was assigned propranolol. During baseline the mean HUI score in both the groups were almost the same ( mean scores in group A and group B were 0.33±0.13 and 0.35±0.11 respectively

Conclusion: The present comparative study between propranolol and flunarizine showed that propranolol was more effective for the prophylaxis of migraine without aura. It can be concluded from the study that propranolol should be used as an agent for the prophylaxis of migraine.

Keywords: Flunarizine, migraine, propranolol.