A Prospective Study to Evaluate Causes and Outcomes of Acute Kidney Injury in Patients of Cirrhosis of Liver in a Tertiary Care Centre

Title: A Prospective Study to Evaluate Causes and Outcomes of Acute Kidney Injury in Patients of Cirrhosis of Liver in a Tertiary Care Centre

Authors: Dr B. Ashok Babu, Dr K.Vidyasagar, Dr R.Ranganadha Rao, Dr M.Madhusudhana Babu

DOI: https://dx.doi.org/10.18535/jmscr/v7i12.131

Abstract

Introduction

Acute kidney injury (AKI) frequently occurs in patients with cirrhosis and was associated with significant mortality.^1,2 mortality in cirrhosis has been shown to increase progressively in association with an increase in the severity of AKI.² The most common causes of AKI in cirrhosis are pre-renal azotemia (volume-responsive pre-renal AKI), acute tubular necrosis (ATN) and hepatorenal syndrome (HRS), a functional type of pre-renal AKI exclusive of cirrhosis that does not respond to volume repletion. Recent studies suggest using the Acute Kidney Injury Network (AKIN) definition of AKI, which closely correlates with mortality in cirrhosis.

Aim of the Study

To study the incidence of different patterns of AKI in cirrhosis.
To evaluate the impact of AKI severity on patient survival

References

D’Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol 2006; 44:217–231. doi: 10.1016/j.jhep.2005.10.013.
du Cheyron D, Bouchet B, Parienti JJ, Ramakers M, Charbonneau P. The attributable mortality of acute renal failure in critically ill patients with liver cirrhosis. Intensive Care Med 2005; 31:1693–1699. doi: 10.1007/s00134-005-2842-7.
Jai Prakash, Amit Kumar Mahapatra, Biplab Ghosh, Puneet Arora and Ashok Kumar Jain Clinical Spectrum of Renal Disorders in Patients with Cirrhosis of Liver Renal Failure, 33(1): 40–46, (2011.
M. Belcher, G. Garcia-Tsao, A. J. Sanyal et al., “Association of AKI With mortality and complications in hospitalized patients with cirrhosis,” Hepatology, vol. 57, no. 2, pp. 753–762, 2013.

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