Abstract
Subclinical Hypothyroidism refers to biochemical evidence of Thyroid hormone deficiency in patients who have few or no apparent clinical features of Hypothyroidism. In practical field, if the patients serum fT4 is within normal limit but serum TSH is elevated then it is considered as Subclinical Hypothyroidism. So Subclinical Hypothyroidism resides in the same spectrum of clinical hypothyroidism In Hypothyroidism there is decreased muscle strength and this may affect Pulmonary functions accordingly.
Objective: To assess Pulmonary Functions in Subclinical Hypothyroidism cases to find out whether there is any significant impairment of lung functions.
Materials and Methods: The study was done in one of the Peripheral Medical Colleges of West Bengal. 100 subjects (50cases and 50 controls) were selected according to age BMI, Inclusion and exclusion criteria. Serum TSH and serum fT4 were measured and spirometric measurement of lung functions were done.
Statistical analysis was done by SPSS-17 and P value < 0.001 was considered as statistically significant.
Result: All the spirometric parameters were significantly decreased in subclinical hypothyroidism as compared with the normal control group.
Keywords: subclinical hypothyroidism, serum TSH, serum fT4, spirometric measurement of lung function.
References
- Fauci, Braunwald, Kasper, Hauser Longo, Jameson, et al. Harrison's Principle of Internal Medicine. Ed – : The McGraw – Hill Companies.
- Kek PC, Ho SC, Khoo DH et al. Subclinical thyroid disease. Singapore Med J 2003 ; ( 44 ) : 595 –600.
- Bhuvaneswari T, KouserBanu K. Evaluation of pulmonary functions in patients with hypothyroidism who are on conservative management. Sch J App Med Sci. 2014 ; 2 ( 2A ): 495 –97.
- Deshmukh V, Behl A, Iyer V, Joshi H et al. Prevalence, clinical and biochemical profile of subclinical hypothyroidism in normal population in Mumbai. Indian J EndocrinolMetab 2013; 17 (3) 454 – 59.
- Unnikrishnan AG, Kaira S, Sahay RK, Bantwal G et al. Prevalence of Hypothyroidism in adults : An epidemiological study in eight cities of India. Indian J EndocrMetab2013; 17: 647 – 52.
- Col NF, Surks MI, Daniels GH et al. Subclinical thyroid disease – clinical application. JAMA 2004; 291 (2): 239 – 43.
- Larsen PR, Davies PF, Williams Text Book of Endocrinogy–2003
- T seng, Lin WY, Lin CC et al. Subclinical Hypothyroidism is associated with increased risk for all cause and cardiovascular mortality in adults. Journal of the American College of Cardiology (JACC). 2012; 60 (8): 730 –37.
- Gupta G, Sharma P, Kumar P et al. Study on Subclinical Hypothyroidism and its association with various inflammatory makers. Journal of Clinical and Diagnostic Research ( JCDR ). 2015; 9 (11): BC04 - BC06.
- Cakmak G, Saler T, SaglamZa et al. Pulm functions in patients with Subclinical Hypothyroidism. J Pak Med Assoc. 2011; 61 ( 10 ): 951 – 53.
Corresponding Author
B Mukhopadhyay
Professor, Department of Physiology, Murshidabad Medical College, West Bengal, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i12.10
