Abstract
Purpose: The objective of this study is to assess the rapidity of progression of retinopathy in pregnant diabetic women during gestational period with correlation with glycemic control.
Materials & Methods: This was a prospective observational study of patients admitted/ visited to the department of Medicine, Endocrinology, Ophthalmology & Obstetrics & Gynecology in a tertiary health care system in State of Odisha during January 2016 to December 2017. The study included total 50 pregnant with diabetes vs 50 non-pregnant diabetes for progression of retinopathy during their gestational period.
Results: At the end of study, 32.5% of cases in the study group showed progression of retinopathy staging during pregnancy as compared to 14% in non-pregnant women. The glycosylated hemoglobin, duration of diabetes, current age was evaluated as risk factors for progression of diabetic retinopathy.
Conclusion: Pregnancy, level of glycemia (HbA1c) & age are risk factors for acceleration of Retinopathy progression.
Keywords: Pregnancy, Diabetic retinopathy, HbA1c.
References
- "About diabetes". World Health Organization. Archived from the original on 31March 2014. Retrieved 4 April 2014.
- Diabetes Programme". World Health Organization. Archived from the original on 26 April 2014. Retrieved 22 April 2014.
- Prediabetes & Insulin Resistance. - The National Institute of Diabetes and Digestive and Kidney Diseases Health Information Center. Retrieved: March 01, 2017.
- Impact of pregnancy on the progression of diabetic retinopathy in Type 1 diabetes. Temple RC, Aldridge VA, Sampson MJ, Greenwood RH, Heyburn PJ, Glenn A Diabet Med. 2001 Jul; 18(7):573-7.
- Changes in diabetic retinopathy during pregnancy. Correlations with regulation of hyperglycemia. Phelps RL, Sakol P, Metzger BE, Jampol LM, Freinkel N. Arch Ophthalmol. 1986 Dec; 104(12):1806-10.
- Temple RC, Aldridge VA, Sampson MJ. et al. Impact of pregnancy on the progression of diabetic retinopathy in Type I diabetes. Diabet Med. 2001;18((7)):573–7.
- Mallika, PS et al. “Diabetic Retinopathy and the Effect of Pregnancy.” Malaysian Family Physician : the Official Journal of the Academy of Family Physicians of Malaysia 5.1 (2010): 2–5.
- Mathiesen ER, Vaz JA (2008) Insulin treatment in diabetic pregnancy. Diabetes Metab Res Rev 24:S3–S20.
- Impact of pregnancy on the progression of diabetic retinopathy in Type 1 diabetes. Temple RC, Aldridge VA, Sampson MJ, Greenwood RH, Heyburn PJ, Glenn Diabet Med. 2001 Jul; 18(7):573-7.
- Kostraba JN, Dorman JS, Orchard TJ, Becker DJ, Ohki Y, Ellis D, Doft BH, Lobes LA, LaPorte RE, Drash AL: Contribution of diabetes duration before puberty to development of microvascular complications in IDDM subjects. Diabetes Care 1989;12:686–693.
- Klein R, Klein BE, Moss SE. Is obesity related to microvascular and macrovascular complications in diabetes? The Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch Intern Med. 1997 Mar 24; 157(6):650-6. PubMed PMID: 9080919.
Corresponding Author
Dr Suresh Chandra Swain
Associate Professor, Dept. of Ophthalmology, SCB Medical College, Cuttack