Abstract

Introduction: Cerebrovascular diseases are one of the most general causes of morbidity and mortality.  Ischemic stroke occurs when blood flow in a vessel is compromised by atherosclerosis plagues and it ultimately leads to thrombus formation. Platelets plays an essential role in the pathophysiology of ischemic stroke by developing intravascular thrombus after erosion or rupture of atherosclerotic plaques. The involvement of blood clot in ischemic stroke demands for effective and constant monitoring of haemostatic parameters such as platelet components in stroke patients in order to properly manage and treat them.

Methods & Material: Considering the best availability of the patients by reviewing the previous records of this health facility to achieve the maximum sample size we randomly screen all patients who have fulfill the inclusion and exclusion criteria and ready to give the written consent. After all aseptic precautions 2ml of blood sample was obtained from antecubital vein of the patient within 48 hours of onset of signs and symptoms of ischemic stroke. Samples were collected in EDTA vials, kept at room temperature. The printout reports of samples fed to MINDRAY-BC 3600 Autoanalyser and collected and analyzed.

Results: There was direct relationship of MPV, PC and PLCR with severity of ischemic stroke and inverse relationship of PDW and PCT with severity of ischemic stroke. PC and PLCR were higher in patient with ischemic stroke but PC showed not significant change whereas PLCR showed significant abnormal changes in ischemic stroke patient.                                                 

Conclusions: Platelet indices are marker of platelet function. Its utility as a risk factor in cases of coronary artery disease is well known. This study shows that MPV is higher in patients of acute ischemic stroke / TIA, hence, it can be regarded as an independent risk factor for ischemic stroke / TIA. Elevated mean platelet volume is associated with more severe morbidity and worse outcome in patients with acute ischemic stroke / TIA. There was direct relationship of MPV, PC and PLCR with severity of ischemic stroke and inverse relationship of PDW and PCT with severity of ischemic stroke.