Lithium Toxicity Causing Neuroleptic Malignant Syndrome

Title: Lithium Toxicity Causing Neuroleptic Malignant Syndrome

Authors: Uthaya Sankar M.K, Naveen Sathish.V, Sibi Chakravarthy.C

DOI: https://dx.doi.org/10.18535/jmscr/v7i11.39

Abstract

Lithium is used as a mood stabiliser. Here we report a case of bipolar disorder on Lithium and Olanzapine presented with fever, generalised rigidity and unconsciousness. He was diagnosed as Neuroleptic malignant syndrome (NMS). His serum lithium level was elevated. Lithium associated NMS usually occurs only in combination with antipsychotics at around 0.01-3%.

References

Patil V, Gupta R, Verma R, Balhara YPS. Neuroleptic malignant syndrome associated with lithium toxicity. Oman Med J. 2016 jul;31:4.
Pope HG, Cole JO, Choras PT, Fulwiler CE. Apparent neuroleptic malignant syndrome with clozapine and lithium. Journal of Nervous and Mental Disease. 1986 Aug.
Keck PE, Pope HG, Cohen BM, McElroy SL, Nierenberg AA. Risk factors for neuroleptic malignant syndrome: a case-control study. Archives of General Psychiatry. 1989 Oct 1;46(10):914-8.

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