Abstract
Aims and Objectives: To study the association of Ischemic Heart Disease in Subclinical Hypothyroidism in women above 50 years of age.
Methods
Case Selection: Women more than 50 years of age attending the Medical outpatient clinic at RAJA MUTHAIAH MEDICAL COLLEGE and HOSPITAL, Chidambaram are screened for the presence of subclinical hypothyroidism based on the presence of biochemical evidence of thyroid hormone deficiency in patients who have few or no apparent clinical features of hypothyroidism. Among the patients screened, 100 patients with subclinical hypothyroidism are included in the study.
Results: 320 women above the age of 50 years who visited the Medical outpatient clinic during the study period were studied.100 women were found to have the criteria set for the definition of subclinical hypothyroidism, which meant a rate of 31.25%, and a total of 23 patients among those had Ischemic heart Disease.
Conclusion: Patients with subclinical hypothyroidism are at risk of developing Ischemic Heart Disease.
References
- Nystrom E, Bengtsson C, Lindquist O et al: Thyroid disease and high concentration of serum thyrotropin in a population sample of women. Acta Med Scan, 1981; 210: 39-46.
- Parle JV, Franklyn JA, Cross KW et al: Prevalence and follow-up of abnormal thyrotropin (TSH) concentration in the elderly in the United Kingdom. Clin Endocrinol, 1991; 34: 77-83
- Vanderpump MPJ, Tunbridge WMG, French M et al: The incidence of thyroid disorder in the community: a twenty-year followup of the Whickham survey. Clin Endocrinol, 1995; 43: 55-68.
- Althaus BU, Staub JJ, Ryff-De Leche A, Oberhansli A, Stahelin HB, 1988:LDL/HDL-changes in subclinical hypothyroidism: possible risk factors forcoronary heart disease. Clin Endocrinol (Oxf) 28:157–163.
- Biondi B, Fazio S, Palmieri EA, Carella C, Panza N, Cittadini A, Bone F,Lombardi G, Sacca L, 1999: Left ventricular diastolic dysfunction in patients with subclinical hypothyroidism. J Clin Endocrinol Metab 84:2064–2067
- Kahaly GJ, 2000: Cardiovascular and atherogenic aspects of subclinical hypothyroidism. Thyroid 10:665–679
- Pucci E, Chiovato L, Pinchera A, 2000: Thyroid and lipid metabolism. Int J Obes Relat Metab Disord 24 (Suppl 2):S109–S112
- Danese D, Arduino G, Ardreoli M, Pontecorvi A: Screening for subclinical hypothyroidism in a flight personal population. Thyroid, 1997; 7: S-61
- Tieche M, Lupi GA, Gutzweller F, Grob PJ, Studer H, Burgi H, 1981:Borderline low thyroid function and thyroid autoimmunity. Risk factors for coronary heart disease? Br Heart J 46:202–206
- Ayala A, Danese MD, Ladenson PW: When to treat mild hypothyroidism. Endocrinol Metab Clin North Am, 2000; 29: 399-415
- Lincolin SR, Ke RW, Kuttch WH: Screening for hypothyroidism in infertile women. J Reprod Med, 1999; 44: 455-57
- Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. NEngl J Med 2001; 344:501-509
- Hak AE, Pols HAP, Visser T et al: Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam study. Ann Intern Med, 2000; 132: 270-78
Corresponding Author
Dr Saritha.K.Narayanan
Associate Professor, Department of General Medicine, Rajah Muthaiah Medical College, Chidambaram, Tamilnadu
DOI: https://dx.doi.org/10.18535/jmscr/v7i11.38
