Title: An Unusual Case of Rhabdomyolysis - Pheniramine Maleate over Dose

Authors: S. Pravin, R. Aswinth, S. Sudharsan

 DOI: https://dx.doi.org/10.18535/jmscr/v7i10.135

Abstract

Antihistamines are effortlessly to be had over the counter medicines, that are frequently taken in overdoses. The typical effect is observed by means of the anticholinergic outcomes of those medicines. We record a case of a suicide in a male, wherein ingestion of antihistamine pheniramine maleate will cause nontraumatic rhabdomyolysis. Rhabdomyolysis and acute renal failure is a hardly ever said but probably serious problem amongst sufferers who present to the emergency after intentional overdoses making early identification intervention important. We also describe the potential mechanism of muscle injury in antihistamine overdose.

Keywords: Antihistamine overdose, pheniramine maleate, rhabdomyolysis.

References

  1. Koeppel C, Tenczer J, Ibe K. Poisoning with over the counter doxylamine preparations: an evaluation of 109 cases. Human Toxicol. 1987; 6: 355–9.
  2. Prendergast BD, George CF. Drug- induced rhabdomyolysis: Mechanisms and management. Postgrad Med J. 1993; 69: 333–6.
  3. Gabow PA, Kaehny WD, Kelleher SP. The spectrum of rhabdomyolysis. Med (Baltimore) 1982; 61:141–52.
  4. Hampel G, Horstkotte H, Rumpf KW. Myoglobinuric renal failure due to drug induced rhabdomyolysis. Human Toxicol. 1983; 2:197–201.
  5. Frankel D, Dolgin J, Murray BM. Non-traumatic rhabdomyolysis complicating antihistamine overdose. J Clin Toxicol. 1993; 31:493–6.
  6. Soto LF, Miller CH, Ognibere AJ. Severe rhabdomyolysis after doxylamine overdose. Postgrad Med. 1993; 93:227–9.
  7. Leybishkis B, Fasseas P, Ryan KF. Doxylamine overdose as a potential cause of rhabdomyolysis. Am J Med Sci. 2001; 322:48–9.
  8. Emadian SM, Caravati EM, Herr RD. Rhabdomyolysis. A rare adverse effect of diphenhydramine overdose. Am J Emerg Med. 1996; 14: 574–6.
  9. Ellenhorn MJ. Ellenhorn's Medical Toxicology, Diagnosis and Treatment of Human Poisoning. 2nd ed. Baltimore: Williams and Wilkins; 1997.
  10. Curry SC, Chang D, Connor D. Drug- and toxin-induced rhabdomyolysis. Ann Emerg Med. 1989; 18:1068–84.

Corresponding Author

S. Pravin