Abstract
Introduction
The role of thyroid hormone is vital in the timing and pace of development of central nervous system of our body during intrauterine life and in the early infancy. If there is a deficiency of thyroid hormone, it will greatly influence the growth of the cerebral and cerebellar cortex, proliferation of axons and branching of dendrites, myelinization and cell migration. Deficiency of thyroid hormones during neural differentiation results in severe and permanent modifications in the morphology and function of the nervous system, in particular a general slowing of cognitive functions with memory impairment and apathy.[1]
One of the manifestations of the hypothyroidism is the peripheral neuropathy. The development of this neuropathy is insidious in onset, which will take a long period of time for clinical manifestations.[2] The severity of the neuromuscular signs and symptoms depends on duration and severity of hormonal deficiency and clinical, electrophysiological and morphological improvement with hormone replacement therapy is typical.[3-5]
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Corresponding Author
Dr Garima Bafna
Senior Professor, Dept. of Physiology, J.L.N. Medical College, Ajmer, Rajasthan, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i9.134
