Abstract
Background: The present study was aimed to comparison the C-reactive protein with microalbuminuria among type 2 diabetic subjects in hypertension.
Introduction: CRP production is part of the nonspecific acute-phase response to most forms of inflammation, infection and tissue damage. The association between CRP and hypertension could be related in part as follows: correlation between elevated CRP and arterial stiffness; association between CRP and metabolic syndrome, one of whose criteria is hypertension and the possibility that CRP may directly contribute to reduced nitric oxide synthesis in endothelial cells, leading to increased vascular resistance.
Material & Methods: The present study includes of 500 type 2 diabetic subject & divided into two groups based on hypertension. Biochemical parameter such as C-reactive protein (CRP) was analysed in the department of biochemistry of NIMS medical college. Hypertension was taken according to definition of WHO; as systolic blood pressure (SBP) ≥140 mmHg and diastolic (DBP) ≥90 mmHg.
Result: There was significant difference between the patient and control groups with regard to age, blood pressure, lipid profile, and CRP. The study also showed significant positive correlations between CRP, age and blood pressure.
Conclusion: The levels of CRP were elevated in hypertensive individuals, which suggests the possibility of an inflammatory pathogenesis in hypertension.
Keywords: C-reactive protein, normotensive, hypertension.
References
- Monaster SH, Ahmed MK, Braik AG. Comparison between strain and strain rate in hypertensive patients with and without left ventricular hypertrophy: a speckle-tracking study. Menoufia Med J 2014;27:322-328.
- Pearson TA, Mensah GA, Alexander RW, Anderson JL, Canon RO, CriquiM, et al. Marker of ibflammation and cardiovascular disease. Circulation 2003;107:499-511.
- Ridker PM, Silvertown JD. Inflammation, C-reactive protein, and atherothrombosis. J Periodontal 2008;79(Suppl):1544-1551.
- Kushner I, Salmpns D, Magray MA. Unifying biologic explanation for highsensitive C-reactive protein and low grade inflammation. Arthritis Care Res (Hoboken) 2010;62:442-446.
- Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J LeukocBiol2007;81:1-5.
- Taddei S, Caraccio N, Virdis A, Dardano A, Versari D, Ghiadoni L. Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimotos J ClinEndocrinolMetab2006;91:5076-5082.
- Maachi M, Pieroni L, Bruckert E, Jardel C, Fellahi S, Hainque B, et al. Systemic low- grade inflammation is related to both circulating and adipose tissue TNF, leptin and IL-6 levels in obse women. Int J Obes Relat Metab Disorder 2004;28:993-997.
- Lakoski SG, Cushman M, Palmas W, Blumenthal R, D’Agostino J, Herrington DM. The Relationship Between Blood Pressure and C- Reactive Protein in the Multi-Ethnic Study of Atherosclerosis (MESA). J Am CollCardiol. 2005 Nov 15;46(10):1869-74.
- Schillaci G, Pirro M, Gemelli F, Pasqualini L, Vaudo G, Marchesi S, et al. Increased C-reactive protein concentration in never-treated hypertension: the role of systolic and pulse pressures. J Hypertens. 2003 Oct;21(10):1841-6.
- Stuveling EM, Bakker SJL, Hillege HL, Burgerhof JGM, de Jong PE, Gans ROB, et al. C-reactive protein modifies the relationship between blood pressure and microalbuminuria. Hypertension. 2004 Apr;43(4):791-6.
- Tsioufis C, Dimitriadis K, Chatzis D, Vasiliadou C, Tousoulis D, Papademetriou V, et al. Relation of microalbuminuria to adiponectin and augmented C-reactive protein levels in men with essential hypertension. Am. J. Cardiol. 2005 Oct 1;96(7):946-51.
- Nakamura M, Onoda T, Itai K, Ohsawa M, Satou K, Sakai T, et al. Association between serum C-reactive protein levels and microalbuminuria: a population-based cross-sectional study in northern Iwate, Japan. Intern. Med. 2004 Oct;43(10):919-25.
Corresponding Author
Dr Suresh Babu Kondaveeti
Associate Professor, Department of Biochemistry, National Institute of Medical Science & Research, NIMS University, Jaipur, Rajasthan
DOI: https://dx.doi.org/10.18535/jmscr/v7i9.131
