Abstract
Background: Oral cancer is a major problem in the Indian subcontinent where it ranks among the top three types of cancer in the country and is eighth most common cancer worldwide. It is often preceded by precancerous or premalignant lesions, and conditions such as- Leukoplakia, Erythroplakia and Oral sub mucosal fibrosis.
Materials and Methods: A total of 142 patients who presented with clinical signs and symptoms of premalignant and malignant Stages of Oral Cancer were enrolled in the study. However, of which, 39 patients were excluded due to- patients expired (n=5); not reported for the next follow up (n=23); posted for radiation (n=2) and for surgery (n=9); during the study period. After exclusion of above 39 patients, 103 patients were eligible to include in the study, of them which, 88 were males and 15 were females.
Results: Socio demographic data of the patients:
In the present study, amongst 103 eligible patients, 88 (85.43%) were males and 15 (14.56%) were females. Majority of the patients were uneducated that constituted 70.87% (n=73) while educated patients was 29.12% (n=30). And also, 67.96% (n=70) of patients were identified from rural area and rest of 32.04% (n=33) from urban area.
Conclusion: In the present study, substantial improvement and decrease in disease severity was observed with selected (Lycopene) antioxidant therapy in different stages of oral cancer patients. Thus, antioxidants are overall favorable for early cases of oral premalignant lesions and conditions to cease and delay the disease progression.
Keywords: Anti oxidant, Lycopene, Oral cancer.
References
- Petersen PE. Strengthening the prevention of Oral cancer: the WHO perspective. Community dentistry and Oral epidemiology. 2005 Dec;33(6):397-9.
- Antonia cardesa, Pieter j Slootweg. Pathology of head and neck. 2006;3:68.
- Bouquot JE, Speight PM, Farthing PM. Epithelial dysplasia of the Oral mucosa—Diagnostic problems and prognostic features. Current Diagnostic Pathology. 2006 Feb 1;12(1):11-21.
- Warnakulasuriya S, Johnson NW, Van der Waal I. Nomenclature and classification of potentially malignant disorders of the Oral mucosa. Journal of Oral pathology & medicine. 2007 Nov;36(10):575-80.
- Textbook of Oral Pathology. 2012;7:50.
- Rai S, Malik R, Misra D, Sharma A. Future prospective and current status of antioxidants in premalignant and malignant lesions of Oral cavity. International Journal of Nutrition, Pharmacology, Neurological Diseases. 2014 Oct 1;4(4):198.
- Selvam NP, Dayanand AA. Lycopene in the management of Oral submucous fibrosis. Asian J Pharm Clin Res. 2013;6(3):58-61.
- Mehrotra R, Nigam SK, Nigam N. Role of antioxidants on oral submucous fibrosis: a clinico–pathological study. J Evolution Med Dent Sci. 2013 Nov 25;2(47):9174-83.
- Wahi PN, Mital VP, Lahiri B, Luthra UK, Seth RK, Arora GD. Epidemiological study of precancerous lesions of the oral cavity: a preliminary report. The Indian journal of medical research. 1970 Oct;58(10):1361-91.
- Mehta FS, Gupta PC, Daftary DK, Pindborg JJ, Choksi SK. An epidemiologic study of oral cancer and precancerous conditions among 101,761 villagers in Maharashtra, India. International Journal of Cancer. 1972 Jul 15;10(1):134-41.
- Zachariah J, Mathew B, Varma NA, Iqbal AM, Pindborg JJ. Frequency of oral mucosal lesions among 5000 individuals in Trivandrum, South India. Preliminary report. Journal of the Indian Dental Association. 1966;38(11):290-4.
- Hazarey VK, Erlewad DM, Mundhe KA, Ughade SN. Oral submucous fibrosis: study of 1000 cases from central India. Journal of oral pathology & medicine. 2007 Jan;36(1):12-7.
- Burungale SU, Durge PM, Burungale DS, Zambare MB. Epidemiological study of premalignant and malignant lesions of the oral cavity. J Academia Industrial Res. 2014 Feb;2:519-23.
- Ahmad MS, Ali SA, Ali AS, Chaubey KK. Epidemiological and etiological study of oral submucous fibrosis among Gutkha chewers of Patna, Bihar, India. Journal of indian society of pedodontics and preventive dentistry. 2006 Apr 1;24(2):84.
- Tang JG, Jian XF, Gao ML, Ling TY, Zhang KH. Epidemiological survey of oral submucous fibrosis in Xiangtan City, Hunan Province, China. Community dentistry and oral epidemiology. 1997 Apr;25(2):177-80.
- Vanaja R, Wanjari PV, Naveen RB, Prashanti R. Oral submucous fibrosis: Correlation of clinical grading to various habit factors. Int J Dent Clin 2011; 03: 21-24.
- Supadminidevi G, Jayanthi K, Bina S, Kamala R. Evaluation between betel quid and pan masala Gutkha habitual chewers with OSMF. World Journal Of Dentistry 2012; 03: 37-40.
- Santhosh P, Sneha M. Proposed new grading of submucous fibrosis based on cheek flexibility.J Clin Exp Dent 2014; 06: 255-258.
- Niranzena PS, Arjun AD. Lycopene in the management of oral submucous fibrosis. Asian J Pharm Clin Res 2013; 06: 58-61.
Corresponding Author
Bachu Brahmani
Mailing address- 33-5-238/4, Naidupump, Warangal, India- 506005
DOI: https://dx.doi.org/10.18535/jmscr/v7i9.118
