Title: Recent trend of clinico-pathological presentation of malignant soft tissue sarcoma patients - a retrospective study at Regional Institute of Medical Sciences (RIMS), Manipur
Authors: Yumkhaibam Sobita Devi, Arindam Bhaumik, Deiwakor Chyrmang, Srigopal Mohanty, Laishram Jaichand singh
DOI: https://dx.doi.org/10.18535/jmscr/v7i9.83
Abstract
Background: Increasing incidence of soft tissue sarcoma (STS) in recent years has created a major health problem. Knowledge of clinical presentation of patients with soft tissue sarcoma may help in planning prevention, early detection and treatment of STS in this region (MANIPUR)
Methods: This is a retrospective case study on 55 cases of STS patients who were registered at Regional Institute of Medical Sciences, Manipur during the period from January, 2015 to December, 2018. The data were analyzed using SPSS-21 and the results were presented in percentage and simple frequency.
Result: Among the patients, the ages ranged from 14 to 81 yrs. Maximum number of patients reaches a peak between 60 - 81 years (56.0%). Painless mass (52%) was the most common presentation, 6% presented with only pain, 32% presented with painful mass. Duration of symptoms was less than 6 months for more than half of the patients (52%). In this study, maximum (42%) of STS cases were found in extremities (upper limb and lower limb), most commonly in the lower extremity (26%). 12%, 8%, 10% and 12% of STS cases were found in retroperitoneum, abdominal wall / trunk, head and neck region and pelvic cavity respectively. Very less number (14%) of cases were found in the other parts of the body. According to this study, we had data on 12 histological subtypes of STS, among which leiomyosarcoma had maximum incidence (22%), followed by fibrosarcoma (12%), liposarcoma (12%) and GIST (12%), sarcoma not otherwise specified (10%) and less percentage of other rare subtypes (malignant fibrous histiosarcoma- 4%, rhabdomyosarcoma-6%, peripheral nerve sheath tumour-4%, extra skeletal ewing’s sarcoma-6%, kaposi’s sarcoma-8%, sarcomatoid mesothelioma-2%, neuroblastoma-2%) also found. In this study, half of the patients (50%) had tumour size of 5-10 cm and 24% patients had node positivity and 18% of patients had metastatic disease at the time of diagnosis.
Conclusion: Majority of the patients was males (52%) and most of the patients were in the age group of 60-81 years. From among the types of STS, leiomyosarcoma has the highest incidence (22%). 42% of STS cases were found in the extremities, most commonly in the lower extremity (26%). At the time of diagnosis, 24% of patients had node positive and 18% had metastatic disease. Knowledge of clinical presentation of patients with soft tissue sarcoma may help in planning prevention, early detection and treatment of STS in this region (MANIPUR)
Keywords: Clinical presentation, Histopathology, Soft tissue sarcoma.
