Abstract
Background: Metabolic syndrome and its individual criteria poses an increased risk for atherosclerotic diseases. Metabolic syndrome is also associated with increase in carotid intima-media thickness, which is a marker of preclinical atherosclerosis. Hence this study was aimed to determine to find out correlation between metabolic syndrome and increase in carotid intimal media thickness.
Methods: All patients with stroke age more 30 years admitted in Department of General Medicine during the study period from May 2017 to April 2020 were included in study. A total of 50 patients presenting with stroke were assessed and were classified as metabolic syndrome or non-metabolic syndrome based on IDF criteria who fulfilled the selection criteria during the study period were enrolled.
Results: Out of 50 stroke patients studied, 29 patients (17 males and 12 females) had metabolic syndrome according to IDF criterion. Occurrence of metabolic syndrome in patients with stroke was 58%. Out of total 29(58%) patients with metabolic syndrome, 17(58.6%) were male and 12(57.1%) patients were. Out of total patients in the study group, 29 patients had increased carotid intimal thickness out of which 21(72.4%) patients had metabolic syndrome with 12(75%) Males and 09(69.23%) Females. It was found to be statistically significant with p value 0.03.
Conclusions: Accelerated rate of atherosclerosis in found in patients with metabolic syndrome and there is increase in CIMT in these patients, so carotid doppler can be used for predicting atherosclerotic changes in such patients in early stages.
Keywords: Atherosclerosis, Carotid intima media thickness, Metabolic syndrome, Carotid Doppler.
References
- Elkind SVM, Sacco RL. Pathogenesis, Classification and Epidemiology of Cerebrovascular Disease. Merritt's Neurology. Section IV. Chapter 37.12thed. Lewis P R, Timothy A P. Lippincott Williams & Wilkins 2010 ; 217-229.
- Alberti KG, Zimmet P, Shaw J. The metabolic syndrome - a new world-wide definition. Lancet. 2005 Sep 24-30;366(9491):1059-62.
- Crouse III JR, Tang R, Espeland MA, Terry JG, Morgan T, Mercuri M. Associations of extracranial carotid atherosclerosis progression with coronary status and risk factors in patients with and without coronary artery disease. Circulation. 2002 Oct 15;106(16):2061-6.
- Kuller L, Borthani N, Furberg C, Gardin J, Manolio T, O'leary D, et al. Prevalence of subclinical atherosclerosis and cardiovascular disease and association with risk factors in the Cardiovascular Health Study. Am J Epidemiol. 1994 Jun 15;139(12):1164-79.
- Francesco D, Erica R, Walter A. The metabolic syndrome and the risk of thrombosis. Haematol. 2007;92:297-9.
- Grundy SM. Definition of metabolic syndrome, Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circ. 2004;109:433‐8.
- O’Leary DH, Bots ML. Imaging of atherosclerosis: Carotid intima-media thickness. Eur Heart J. 2010 Jul;31(14):1682-9.
- Koskinen J, Kahonen M, Viikari JS, Taittonen L. Conventional CV risk factors and MetS in predicting carotid intima-media thickness progression in young adults. The CV risk in young Finns study. Circulation. 2009;120:229-36.
- Timóteo AT, Carmo MM, Ferreira RC. Can metabolic syndrome presence predict carotid intimamedia thickness? J Clin Hypertens (Greenwich). 2012;14(8):507-13.
- Zanchetti A, Hennig M, Baurecht H, Tang R, Cuspidi C, Carugo S, et al. Prevalence and incidence of the metabolic syndrome in the European Lacidipine Study on Atherosclerosis (ELSA) and its relation with carotid intima–media thickness. Journal of hypertension. 2007 Dec 1;25(12):2463-70.
- O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr: Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340:14- 22,199.
- Koshiyama H, Shimono D, Kuwamura N, Minamikawa J, Nakamura Y: Rapid communication: inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab2001;86:3452-3456.
- Eguchi K, Kario K, Shimada K: Greater impact of coexistence of hypertension and diabetes on silent cerebral infarcts. Stroke 2003;34:2471-2474.
- Johnsen SH, Mathiesen EB: Carotid plaque compared with intimamedia thickness as a predictor of coronary and cerebrovascular disease. CurrCardiol Rep 2009;11:21-27.
Corresponding Author
Dr Vaja Mukhtarahmed
C1-606 Mahindra Antheia, Nehrunagar, Pimpri, Pune-411018, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i9.79
