Abstract

Background: Polymorphic light eruption (PLE) is a very common photosensitive disorder worldwide where elevated titers of antinuclear antibodies (ANA) were found in PLE patients.

Objective: In this study our main aim is to detect whether ANA positivity is associated with an increased risk for development of PLE.

Methodology: This cross sectional study was done at US Bangla Medical College and Hospital and different private chamber in Dhaka district from two years January 2018–July 2019 among 100 patients. Consent was taken from all the patients before the inclusion into the study. Our study consisted of 50 patients and 50 healthy age and gender matched controls who attended the outpatient Department of Dermatology, STD and Leprosy an associated hospital of Dhaka. Automatic immunoassay analyzer (ELISA test) was done to measure ANA index.

Result: During the experiment most of the patients belongs to 31-40 years age group and male percentage (80%) was higher than female. Also, in case group only 7% shows ANA positivity whereas in control group 2% patients shows ANA positivity.

Conclusion: from our result, we can conclude that there was a very little difference in the ANA positivity rate between cases and controls and also of the levels of ANA with the severity of disease. Long-term follow-up of the patients is being undertaken to describe more fully the disease course and prognosis.

Keyword: Polymorphic light eruption (PLE), antinuclear antibodies (ANA), dermatology.