Abstract
Periodontal disease and cardiovascular disease are both multifactorial disease with a high prevalence worldwide. Cross-sectional and longitudinal prospective clinical studies show some evidence for a bidirectional relationship. Periodontitis and cardiovascular diseases share some common risk factors and there exist a mechanistic link between both. Earlier concepts of pathogenesis of cardiovascular events had lipid centric view of etiology. However, in recent years, there has been a shift towards importance of inflammatory processes in the body to be responsible for the disease. In spite of the rising prevalence of both diseases, many people remain unaware of their association with each other. Hence, this review article summarizes the potential link mechanisms in the association between periodontitis and cardiovascular diseases.
Keywords: Cardiovascular diseases, Periodontitis, Infection, Inflammation, Risk factors, Atherosclerosis.
References
- Cutler CW, Kamlar JR, Genco CA. Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis. Trends Microbiol1995;3:45-51.
- Mattila KJ, Nieminen MS, Valtonen, VV, Rasi VP, Kesaniemi YA, Syrjala SL. Association between dental health and acute myocardial infarction. BMJ1989;298:779-781.
- Hujoel PP, Drangsholt M, Spiekerman C, DeRouen TA. Periodontal disease and coronary heart disease risk. JAMA 2000;284:1406-10.
- Cardiovascular Diseases (CVDs). World Health Organization, World Health Organization, May 2017.
- Paquette DW. The periodontal infection-systemic disease link: A review of the truth or myth. J Int Acad Periodontol2002;4:101-109.
- Iacopino AM, Cutler CW. Pathophysiological relationships between periodontitis and systemic disease: Recent concepts involving serum lipids. J Periodontol2000;71:1375-1384.
- Lund Håheim L, Olsen I, Nafstad P, Schwarze P, Rønningen KS. Antibody levels to single bacteria or in combination evaluated against myocardial infarction. J Clin Periodontol 2008;35:473-8.
- Ebersole JL, Taubman MA. The protective nature of host responses in periodontal diseases. Periodontol 2000 1994;5:112-41.
- Moore LV, Moore WE, Cato EP, Smibert RM, Burmeister JA, Best AM, et al. Bacteriology of human gingivitis. J Dent Res 1987;66:989-95.
- Gibbons RJ. Bacterial adhesion to oral tissues: A model for infectious diseases. J Dent Res 1989;68:750-60.
- Page RC, Kornman KS. The pathogenesis of human periodontitis: An introduction. Periodontol 2000 1997;14:9-11.
- Pattnaik NK, Das SN, Biswal BN. Cardiovascular Diseases and Periodontal Diseases: Review and Update. Int J Sci Stud 2017;5(1):239-44.
- Dorn JM, Genco RJ, Grossi SG, Falkner KL, Hovey KM, Iacoviello L, et al. Periodontal disease and recurrent cardiovascular events in survivors of myocardial infarction (MI): The Western New York acute MI study. J Periodontol 2010;81:502-11.
- Beck JD, Slade GD, Offenbacher S. Oral disease, cardiovascular disease and systemic inflammation. Periodontol 2000; 23: 110.
- Armitage GC. Periodontal infections and cardiovascular diseases-how strong is the association. Oral Dis 2000; 6: 335-50.
- Benjamin IJ, McMillan DR. Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circulation Res 1998; 83: 117-32.
- Cutler CW, Shinedling EA, Nunn M, Jotwani R, kim BO, Nares S etal. Association between periodontitis and hyperlipidemia: Cause or effect? J Periodontol 1999; 70: 1429-34.
- Mendall MA, Patel P, Asante M, Ballam L, Morris J, Strachan DP, et al. Relation of serum cytokine concentrations to cardiovascular risk and association with coronary heart disease. Heart 1997; 78: 273-77.
- Bhateja S, Arora G. Cardiovascular Diseases and Periodontal diseases: Exploring the Connection: A Review. Journal of Cardiology and Therapy 2014; 1(8): 181-83.
- Mattila KJ, Valtonen V, Nieminen M, Huttunen JK. Dental infections and the risk of new coronary events: Prospective study of patients with documented coronary artery disease. Clin Infect Dis. 1995;20:588–90.
- DeStefano F, Anda RF, Kahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary heart disease and mortality. 1993;306:688–91.
- Beck J, Garcia R, Heiss G, Vokonas PS, Offenbacher S. Periodontal disease and cardiovascular disease. J Periodontol. 1996; 67:1123–37.
- Joshipura KJ, Rimm EB, Douglass CW, Trichopoulos D, Ascherio A, Willett WC. Poor oral health and coronary heart disease. J Dent Res. 1996;75:1631–36.
- Genco RJ, Chadda S, Grossi S, Dunford R, Taylor G, Knowler W, et al. Periodontal disease is a predictor of cardiovascular disease in a Native American population. J Dent Res. 1997;76:3158.
- Arbes SJ, Jr, Slade GD, Beck JD. Association between extent of periodontal attachment loss and self reported history of heart attack: An analysis of NHANES III data. J Dent Res. 1999;78:1777–82.
- Genco RG, Wu TJ, Grossi S, Genco RJ, Wu TJ, Grossi S, et al. Periodontal microflora related to the risk for myocardial infarction; a case control study. J Dent Res. 1999;78:457.
- Janket SJ, Baird AE, Chuang SK, Jones JA. Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 2003;95:559–69.
- Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease and stroke: A systematic review. Ann Periodontol. 2003;8:38–53.
- Blaizot A, Vergnes JN, Nuwwareh S, Amar J, Sixou M. Periodontal diseases and cardiovascular events: Meta-analysis of observational studies. Int Dent J. 2009;59:197–209.
- Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: A proposal for reporting Meta- analysis of observational studies in epidemiology (MOOSE) group. JAMA 2000;283:2008–12.
- Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E. Relation between periodontal infection and C- reactive protein. J Periodontol. 2001; 72:1221–27.
- de Oliveira C, Watt R, Hamer M. Tooth brushing, inflammation and risk of cardiovascular disease: Results from Scottish Health Survey. BMJ. 2010; 340:c2451
- Ebersole J, Machen R, Steffen M, Wilmann D. Systemic acute phase reactants, C-reactive protein and haptoglobin in adult periodontitis Clin ExpImmunol. 1997;107:347–52.
- Dhadse P, Gattani D, Mishra R. The link between periodontal disease and cardiovascular disease: How far we have come in last two decades ? J Indian Soc Periodontol. 2010 Jul-Sep;14(3):148-54.
Corresponding Author
Dr Anisha Avijeeta
DOI: https://dx.doi.org/10.18535/jmscr/v7i7.162
