Title: Comparative study of anti-inflammatory effect of diclofenac and aceclofenac on human
Author: Dr Amit Kumar Jha
DOI: https://dx.doi.org/10.18535/jmscr/v7i7.143
Abstract
Various exogenous and endogenous stimuli incite a complex reaction in vascularized connective tissue called inflammation. Non steroidal anti inflammatory drugs are used to reduce inflammation. Preferential COX-2 inhibitors namely diclofenac and aceclofenac was taken for my present work and anti inflammatory effect was compared with control and with each other. Student-t-test-was done to compare result. It was found that inflammation varied significantly across the three groups (P=.000) Compared to control, inflammation was less in both diclofenac and aceclofenac (P=.00). Reduction of inflammation with diclofenac was less. In comparision to aceclofenac at end. Aceclofenac is more efficacious than diclofenac.
Keywords: Aceclofenac, diclofenac, Anti inflammatory effect.
