Abstract
Introduction: Preterm and term infants are more frequently exposed to high concentrations of oxygen for prolonged periods. When supplemental oxygen is needed for care, it will be prudent to avoid fluctuations in SpO2. The definition of the safest level of oxygen saturations in the neonate remains an area of active research. On the basis of the recently published evidences, the most suitable approach would be to set an alarm limits between 90 and 95%.
Objective: To reduce the inappropriate use of O2 (concentration and duration) by implementation of standard protocol, which is done by quality improvement strategy.
Materials and Methods: This is a quality improvement study conducted in a tertiary care children’s health institution in India. Pre interventional and post interventional data are collected from hospital records of 69 and101 hospitalized newborn cases respectively. By Q.I method, first prioritization of problem and research team formation, then clear aim statement about study is discussed prior to data collection. In 2nd step analysis of problems and the team members tried to solve this problem by using the fish bone analysis method. Then the changes are made as per PDSA cycle (CME about implementation of new protocol, reorientation of staffs, some changes made in emergency department. Initially smaller changes then multiple and larger events done). The final data are analyzed and compare with baseline data.
Results: There reduction of duration and concentration of O2 use is observed as < 2 days duration in final data i.e 69.7% which is significantly more than base line data (23%). Appropriate use of O2 among neonates is significantly increased after implementation of quality improvement strategy (67.96%) over base line data (19%). In final data mean O2 therapy is 1-2 days in comparison with base data i.e 3-5 days. There are no significant changes in outcome parameters.
Conclusion: Practice recommendation of O2 saturation targets newborn cared with minimizing oxygen therapy and toxicity.
Keywords: Oxygen, newborn, SPO2, preterm, free radicals.
References
- http://www.everypreemie.org/wp-content/uploads/2017/07/Oxygen_7.6.17.pdf last assessed on 25.10.18
- Melinda Paul, CRNP, NNP-BC. Oxygen Administration to Preterm Neonates in the Delivery Room: Minimizing Oxidative Stress .Advances in Neonatal Care. April 2015( 15 ) 2 : 94 – 103.
- Perrone S, Bracciali C, Di Virgilio N, Buonocore G. Oxygen Use in Neonatal Care: A Two-edged Sword. Front. Pediatr. 2017;4:143. doi: 10.3389/fped.2016.00143
- https://extranet.who.int/rhl/topics/newborn-health/care-newborn-infant/who-recommendation-oxygen-therapy-preterm-newborns.Updated on 17th Nov ,2015. Last assessed on 19.07.2019.
- Yesmin Ozsureci and Kubra Aykac. Oxidative related diseases in newborn. Medicine and cellular longivity. 2016; article ID 2768365; 9 pages
- Serafina Perrone, Maria Luisa Tataranno, Gemma Stazzoni, Giuseppe Buonocore. Oxidative stress and free radicles related diseases in newborn. Advances in Bioscience and Biotechnology. 2012; (3):1043-1050.
- Sindhu Sivanandan, Tavpritesh sethi, Rakesh Lodha, Anu thukral, M Jeeva sankar, Ramesh Agarwal1, Vinod K Paul1 and Ashok K Deorari. Target Oxygen Saturation Among Preterm Neonates on Supplemental Oxygen Therapy: A Quality Improvement Study. Indian Paediatrics.2018; (55)
- Lisa Baba, Jacqueline McGrath. Oxygen Free Radicals: Effects in the Newborn Period. Advance neonatal care. Nov.2008; 8(5): P. 256-264
- Nicola Austin. Practice recommendation for Oxygen saturation targets for newborns cared for in neonatal units, on behalf of newborn clinical network clinical reference group; New Zealand, Review date 31.08.2017.
- Improving the quality care for mother and newborn in health facilities: pocqi learners manual vol.2 2017
- https://medlineplus.gov/ency/article/007242.htm,last updated 11.112018,last assessed on 19.07.2019
- Augusto Sola. Oxygen Saturation in the Newborn and the Importance of Avoiding Hyperoxia-Induced Damage. Neo Reviews. July, 2015;(16)7. https://neoreviews.aappublications.org/content/16/7/e406. last updated July,2015, Last assessed on 19.07.2019.
- Bhandari V. Molecular mechanisms of hyperoxia-induced acute lung injury. Front. Biosci. 2008;13: 6653-6661.
- F. Araneda, M. Tuesta.Lung Oxidative Damage by Hypoxia Oxidative Medicine and Cellular Longevity. Volume 2012, Article ID 856918, 18 pages
- Oxygen therapy in newborn Neonatal clinical practice guidelines: Winnipeg regional health authority: appropriate date march 2015; page 1-4
- Askie LM, Henderson-smart DJ, Irwing L, Simpson JN. Oxygen saturation targets and out comes in extremely preterm infants. New Engl. J Med 2003; 349: 959-967.
- M. Pisochi and A. Pop. The role of antioxidants in the chemistry of oxidative stress: a review. European Journal of Medicinal Chemistry. 2015; 5( 97): 55–74.
Corresponding Author
Narendra Behera
Associate Prof. Pediatric, S.C.B Medical College, Cuttack, India