Title: The blood glucose lowering effect of ethanolic extract of Emblica officinalis fruit in alloxan induced hyperglycaemic rats
Authors: Dr Zubaida Kha, Ferdous Ara, Onayza Yasmeen, Israt Jahan, SharminNahar, Sheikh Nazrul Islam
DOI: https://dx.doi.org/10.18535/jmscr/v7i7.122
Abstract
Objective: in this study our main goal is to evaluate effect of 500 mg/kg b.w ethanolic extract of Emblica officinalis in alloxan induced hyperglycaemic rats& compare with the anti-diabetic drug Glibenclamide in lowering blood glucose level.
Method: this experimental type of study was conducted at Department of Pharmacology and Therapeutics of Sir Salimullah Medical College in collaboration with Institute of Nutrition & Food Science (INFS) and Department of Pharmaceutical Chemistry of the University of Dhaka from January 2013 to December 2013 where 24 healthy Swiss Albino rats were tested during the study.Data was processed and analyzed.
Result: during the study in normal control group (Group A), the blood glucose levels (mean ± SD) was 5.18 ± 0.14 mmol/L where as the serum glucose concentration in Alloxan treated group (Group B) was 12.35 ± 0.42 mmol/L. Also, the mean ± SD of serum glucose concentration in ethanolic extract group C was 7.7± 0.18 m mol/ L and in Glibenclamide treated group (group D) was 6.4± 0.30 m. mol/L.
Conclusion: from many examination, we can suggest that, the glucose lowering effect of 500mg doses of ethanolic extracts of E.officinalisis almost near effective to that of glibenclamide. So, ethanolic extract of Emblica officinalis may offer an alternate treatment for type II diabetes and its complications.
Keyword: Diabetes mellitus, ethanolic extract, Emblica officinalis.
