Abstract
Introduction: To evaluate the relative efficacy of Gloriosa superba, Valeriana wallichii and Odenlandia corymbosa extracts and atorvastatin in correcting the dyslipidemia induced by feeding high cholesterol diet to rats.
Methods: The study was carried out on healthy male adult rats of Wistar strain. Dyslipidemia was induced by feeding them fructose-rich high fat diet (F-HFD). Gloriosa superba extract, Valeriana wallichii extract, Odenlandia corymbosa extract and atorvastatin were given orally for 30 days along with F-HFD to four different groups. Serum lipids and lipoproteins were measured.
Results: Feeding F-HFD for 30 days led to dyslipidemia in the form of raised serum cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and free fatty acids. In the rats fed F-HFD + Valeriana wallichii extract, serum cholesterol, triglycerides and VLDL-cholesterol were significantly lower as compared to rats fed F-HFD alone. No such effect was seen in the rats given F-HFD + Gloriosa superba extract and F-HFD + Oldenlandia corymbosa extract. In the rats fed F-HFD + atorvastatin, serum lipids were significantly lower as compared to rats fed F-HFD alone and the effect was stronger than that of Valeriana wallichii.
Conclusion: Valeriana wallichii possesses anti-dyslipidemic activity but is not as effective as atorvastatin.
Keywords: Anti-dyslipidemic, Gloriosa superba, Valeriana wallichii, Odenlandia corymbosa.
References
- Bamba V, Rader D. Obesity and Atherogenic Dyslipidemia. Gastroenterology 2007;132(6):2180-90.
- Eaton CB. Hyperlipidemia. Prim Care Clin Office Pract 2005; 32:1027–55.
- Tailor AM, Peeters PH, Norat T, Vineis P, Romaguera D. An update on the prevalence of the metabolic syndrome in children and adolescents.cInt J PediatrObes 2010;5(3):202–13
- Joshi SR, Anjana RM, Pradeepa R et al. Prevalence of dyslipidemia in urban and rural India: the ICMR INDIA study. PLoS One 2014;9 (5).
- Mula-Abed WS, Chilmeran SK. Prevalence of Dyslipidemia in the Iraqi Adult Population. Saudi Medical Journal 2007;28(12):1855-7.
- Delsing DJ, Jukema JW, van de Wiel MA et al. Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in Apo E* 3-Leiden transgenic mice. J CardiovascPharmacol 2003;42(1): 63-70.
- Tripathi I, Nighuntu R. 4th Varanasi: Chaukhambha Krishnadas Academy; 2006.pp.41-42.
- Hirano T, Ito Y, Saegusa H, Yoshino G. A novel and simple method for quantification of small, dense LDL. J Lipid Res. 2003; 44(11):2193-2201.
- Friedewald WT, Levy RI, Fredrickson DS.Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18(6):499-502.
- Mosinger F. Photometric adaptation of Dole's microdetermination of free fatty acids. J Lipid Res. 1965;6(1):157-159.
- Chan KM, Delfert D, Junger KD. A direct colorimetric assay for Ca2+vstimulated ATPase activity.Anal Biochem. 1986;157(2):375-380.
- Albers JJ, Chen CH, Adolphson JL. Lecithin: cholesterol acyltransferase (LCAT) mass; its relationship to LCAT activity and cholesterol esterification rate. Journal of Lipid Research. 1981;22(8):1206-13.
- Wing DR, Robinson DS.Clearing-factor lipase in adipose tissue.A possible role of adenosine 3′, 5′-(cyclic)-monophosphate in the regulation of its activity.Biochemical Journal. 1968;109(5):841-9.
- RaoRS, MisraA, Sharma SK. Recent trends in epidemiology of dyslipidemias in India. Indian Heart Journal 2017; 69: 382–392.
- Zanguei Z, Jowhary H. Hydroalcoholic Extract of Valerian, Blood Factors, and Atherosclerotic Plaque Formation in Male Hypercholesterolemic Rabbits. Biomed Pharmacol J 2015;8(2).
Corresponding Author
Kislay Awasthi
National Institute of Medical Sciences, Jaipur-303121 (Raj)
DOI: https://dx.doi.org/10.18535/jmscr/v7i7.100
