Abstract
Introduction: Developing a receptive endometrium for implantation of the embryo during In vitro fertilization (IVF) treatment is considered the rate-limiting step for its success. Recurrent implantation failure (RIF) has always been a difficult situation to deal with. Our Objective was to evaluate the role of hysteroscopic endometrial scratching in improving the implantation rate and the pregnancy outcome in IVF-ET (embryo transfer) cycles in women with RIF.
Materials and Methods: We did a prospective study including 58 patients with RIF and sonologically normal endometrium, who underwent IVF-ET between September 2016 and August 2018. Of these 32 women underwent hysteroscopic endometrial scratching in the previous cycle whereas 26 of them did not undergo the procedure. The implantation rate, overall pregnancy rate, clinical pregnancy rate and live birth rate were compared between the two groups.
Results: The implantation rate in patients who underwent hysteroscopic endometrial scratching prior to IVF-ET was comparable to that in the subjects who did not undergo the procedure (18.8% versus 13.2%, p= 0.569). The overall pregnancy rate (40.6% versus 38.5%, p= 0.87), clinical pregnancy rate (37.5% versus 34.6%, p= 0.82) and live birth rate (21.9% versus 19.2%, p= 0.80) were also comparable between the two groups.
Conclusion: Our study did not show statistically significant improvement in the pregnancy outcome after hysteroscopic endometrial injury in IVF-ET cycles. Hysteroscopic endometrial injury in IVF -ET cycles in women with recurrent implantation failure may not be beneficial in improving the pregnancy outcome.
Keywords: Endometrial scratching, Pre – IVF hysteroscopy, Recurrent implantation failure, Endometrial receptivity, IVF embryo transfer, Endometrial injury.
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Corresponding Author
Dr Fessylouis T
Associate Professor, Dept of Reproductive Medicine and Surgery, Amrita Institute of Medical Sciences, Kochi, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i7.95
