Abstract
Introduction: Letrozole, is a third generation non-steroidal selective reversible and highly potent aromatase inhibitors which was used in breast cancer is a new drug used for ovulation induction. The present study aims to assess safety and efficacy of the use of letrozole in the patient undergoing ovulation induction, to determine ovulation rate, to evaluate the effect of letrozole on uterine endometrial thickness and to study the final success rate of treatment in terms of pregnancy rate
Material and Methods: A total 60 patients attending with primary and secondary infertility were included in the study. All women were given tablet letrozole 5mg daily from day 2 of the mensis for 5 day. Patients were followed up for maximum up to three cycles.
Results: 60 women of the reproductive age group were studied. Mean age of the women was.27±3.47 years. 52 Women (86.66%) had primary infertility and eight women (13.33%) had secondary infertility. Mean number of follicles in first cycle was 1.47±0.66, mean number of follicles in second cycle was1.70±0.66, mean number of follicles in the third cycle was 1.62±0.66. Average number of dominant follicle was 1.58 ± 0.66. Out of 155 cycle total number of pregnancies was 10, pregnancy rate per cycle was(10/155) 6.45 % , pregnancy rate per ovulatory cycle was (10/129) 7.75% and cumulative pregnancy rate was(10/60) 16.66%.
Conclusions: Letrozole can be used as effective ovulation inducing agent, with no case of multiple pregnancy in the present study. However long-term multicenter randomized case controlled trials are needed with large sample size to conclude about the efficacy and safety of the drug, especially to study long term effect in fetal life, infancy and beyond.
Keywords: Letrozole, Primary infertility, Secondary infertility, Ovulatory cycles, Ovulation induction, Cumulative pregnancy rate.
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Corresponding Author
Dr Vijay Singh Nahata
Assistant Professor, Mahatma Gandhi Medical College, Jaipur, Rajasthan, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i7.82
