Abstract
Introduction: Children undergoing surgical procedures can experience significant anxiety and distress during perioperative period. Sedation in preoperative room remains one of the widely used methods. Intranasal route is preferred, as it is noninvasive and more convenient.
Aim: To compare the efficacy of intranasal dexmedetomidine and Intranasal midazolam for paediatric premedication.
Method: In this prospective, randomised controlled trial 100 patients of 2 to 9 years of age of either sex belonging to ASA class 1 and 2 Undergoing various elective surgery were divided into two groups. Group-1 received 0.2 mg / kg intranasal midazolam, group-2 received 1mcg/kg Intranasal dexmedetomidine 45-60 minutes prior to induction.Onset ofsedation, degree of sedation, parent separation anxiety scale, acceptance of mask, venipuncture score were assessed.
Results: The mean onset of sedation were higher in Group 2(19.34±4.16 Vs 15.46±5.09) which was statistically significant (P=.001). Mean sedation score were lower in group 2(2.6±0.61 Vs 2.98±0.59) which was statistically Significant (P=0.003). The Mean acceptance of mask score were lower In group 2(1.2±0.49 Vs1.54±0.73) which was statistically significant (P =0.008).The mean venipuncture score were lower in group 2(2.06±0.31 Vs 2.18±0.39) which was Statistically Insignificant (P=0.09).The mean parental separation anxiety scale were lower in group 2 (1.38±0.57 Vs 1.66±0.74) which was statistically significant (P <0.03).
Conclusion: Intranasal dexmedetomidine results in higher sedation level, better parental separation and better acceptance of mask thanintranasal midazolam but has slower onset of action than midazolam. Both the drugs having similar response to cannulation.
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Corresponding Author
Vandana Gupta
Resident, Department of Anaesthesia, Sardar Patel Medical College & AGH, Bikaner, Rajasthan, India
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v7i4.157
