Title: Outcome of Sofosbuvir and Ribavirin based treatment in genotype 3 of cirrhotic chronic hepatitis C patients
Authors: Raese Noor Khan, Aadil Bashir Rather, Mohsin Rashid, Prof. Gul Javaid
DOI: https://dx.doi.org/10.18535/jmscr/v7i4.141
Abstract
Introduction: Hepatitis C virus is a leading cause of chronic liver disease in both industrialized and developing countries. Considering the high prevelance of chronically infected individuals, the burden of disease and the absence of a vaccine, treatment forms part of the control of the disease. Sofosbuvir is a pyrimidine nucleotide analogue with high anti-viral activity against all genotypes and shows a high genetic barrier to resistance
Aims and Objectives: The aim of this study is to assess the Outcome of Sofosbuvir and Ribavirin based treatment in genotype 3 of cirrhotic chronic hepatitis C patients.
Materials and Methods: This was a prospective study carried in the department of Gastroenterology Sheri Kashmir Institute of medical sciences soura between 2015 to 2016 involving chronic cirrhotic hepatitis C patients of Genotype 3 with age more than 18yrs. Data analysis was performed using the IBM SPSS version 22.
Results and Observations: In this prospective study the total number of patients was (n=29). The mean age (in years) of patients was (41.2 ±11.77). The number of male patients was 11 (37.93%) and of female patients wa18s (62.06%). The number of cirrhotic patients in treatment naïve group was (n=23) while that in treatment experienced group was (n=6).On comparison on the basis of sustained virological response at twelve weeks of the completion of treatment (SVR12) we observed that treatment naïve cirrhotic patients had (SVR12=100%) while in the treatment experienced non cirrhotic patients (SVR12=66.7%).Sustained virological response (SVR12) among male and female patients was statistically not significant.
Conclusion: The sofosbuvir and ribavirin based therapy shows potentially good rates of sustained virological response in patients with chronic hepatitis C genotype 3 patients and is cost effective and easy to adminster.
Keywords: Hepatitis C; Genotype 3;treatment.
