References

1. Hargrave D, Bartels U, Bouffet E. Diffuse brainstem glioma in children: critical review of clinical trials. Lancet Oncol.2006;7(3):241–8.
2. Mandell LR, Kadota R, Freeman C, et al. There is no role for hyperfractionated radiotherapy in the management of children with newly diagnosed diffuse intrinsic brainstem tumors: results of a Pediatric Oncology Group phase III trial comparing conventional vs. hyperfractionated radiotherapy. Int J Radiat Oncol Biol Phys. 1999;43:959–964. [PubMed]
3. Chassot A et al. Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma. J Neurooncol. 2012;106(2):399–407. No benefit was found from the addition of TMZ to RT for the treatment of DIPG.
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10. Survival rates and prognostic predictors of high grade brain stem gliomas in childhood:a systematic review and  meta-analysis Hadeel Hassan1,2  · Anne Pinches  Susan V. Picton2  · Robert S. Phillips
11. Brainstem Glioma: A Review Sean A. Grimm & Marc C. Chamberlain
12. Bartels U et al. Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG. J Neurooncol. 2011;105 (1):119–25. This is a transcript of a meeting of DIDG experts that discusses state-of-the-art treatment and basic/translational research in the field.
13. Kretschmar CS et al. Pre-irradiation chemotherapy and hyperfractionated radiation therapy 66 Gy for children with brain stem tumors. A phase II study of the Pediatric Oncology Group, protocol 8833. Cancer. 1993;72(4):1404–13.
14. Sharp JR et al. A multi-centre Canadian pilot study of metronomic temozolomide combined with radiotherapy for newly diagnosed paediatric brainstem glioma. Eur J Cancer. 2010;46(18):3271–9.
15. Jenkin RD et al. Brain-stem tumors in childhood: a prospective randomized trial of irradiation with and without adjuvant CCNU, VCR, and prednisone. A report of the Childrens Cancer Study Group. J Neurosurg. 1987;66(2):227–33.

Corresponding Author

Dr Rajan Yadav

Assistant Professor, Department of Radiation Oncology, Gujarat Cancer and Research, Institute, Ahmedabad, Gujarat, India