Abstract
Background: Parkinsonism is a clinical syndrome of akinesia, with or without rigidity, tremor, and postural and gait disturbance. It may be caused by primary degenerative conditions of the brain involving the basal ganglia. We conducted this study with the aim to study the demographic and clinical features of patients with degenerative Parkinsonism presenting to Indraprastha Apollo Hospitals.
Methods: A prospective observational study was conducted at Indraprastha Apollo Hospital between September 2014 and June 2016.A total of 80 patients were enrolled for the study after taking an informed written consent. Among the 80 patients, 40 patients were typical Parkinson’s disease patients and the other 40 were atypical Parkinsonism patients.
Results: In this study we recruited a total of 80 patients which included 40 patients of parkinsonism and 40 patients of atypical parkinsonism. Among the parkinsonism patients, 27 (67.5%) were males, 3 (7.5%) had family history of parkinsonism and 28(70%) were on levodopa-carbidopa therapy. The mean age among typical parkinsonism patients was 66.25±10.55 (mean±SD), mean age of disease onset was 60.64±11.76 and mean duration of the disease was 5.65±4.54. The mean Hoehn and Yahr was 2.54.The mean UPDRS (stage 1-3) was 45.98±21.98 and the mean UPDRS (stage 3) was 31.53±17.39. According to UPDRS part 1- item 4, the mean apathy score was 0.11±0.21), the mean HAMD score in typical Parkinsonism was 6.13±7.66, and mean MMSE score in was 27.75±4.64.
Conclusion: Our study demonstrated socio-demographic and clinical presentation of Parkinsonism patients in our setup. Most common comorbid conditions were also identifies.
Keywords: Parkinsonism, atypical parkinsonism, neurological diseases.
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Corresponding Author
Dr Shubana Ashraf
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DOI: https://dx.doi.org/10.18535/jmscr/v7i4.55
