Abstract
Objective: Present study was undertaken to evaluate the efficacy of plasma rich in growth factors (PRGF) for the treatment of dry eye.
Material and Methods: A total of 62 patients suffering from dry eye problems were included in the study. These patients did not respond previously to other standard treatments. PRGF treatment was given topically in these patients. We quantified several growth factors present in the PRGF of each patients and record the data of the symptoms (modified score dry eye questionnaire), both before and after PRGF treatment.
Result: Out of 62 patients, 48 (77.41%) patients treated with PRGF have no further treatment been required, whereas in the remaining 14 patients (22.59%) other ocular treatments could be reduced. Significant improvement in score of dry eye questionnaire value was observed after PRGF treatment.
Conclusion: PRGF treatment led to improvement in the symptoms in patients with moderate or severe dry eye.
Keywords: Dry eye, Plasma growth factors, Symptoms, treatment.
References
- Fox RI, chan R, Michelson JB, et al. Beneficial effects of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. Arthritis Rheum 1984; 27:459-61.
- Tsubota K, Gato E, Fujita H, et al. Treatment of dry eye by autologous serum application in sjogren’s syndrome, Br. J ophthalmol 1999;83:390-5.
- Pflugfelder SC, soloman A, stern ME. The diagnosis and management of dry eye : A twenty five year review. Cornea, 2000;19:644-649.
- Nelson JD, Drake MM, Brewer JTJ, et al. Evaluation of a physiological tear substitutis in patients with keratoconjunctivitis sicca. Adv. Exp Med Biol 1994;350:453-7.
- Tseng SC, Tsubota, K, Important concepts for treating ocular surface and tear disorders Am J ophthalmol, 1997;124:825-835.
- Kojima T, Ishida R, Dogru M, of al. The effect of autologus serum eye drops in the treatment of severe dry eye disease; a prospective randomized case control study Am J ophthalmol 2005;139:242-246.
- Anitua E, Anida I, Ardanza B, et. Autologous platelets as a source of protein for healing and tissue regeneration Thromb Haemost. 2004;91:4-15.
- Antiua E, Anida I et al. Autologous preparation rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture J orthop Res.
- Poon AC, Geerling G, Dart JK. Autologous serum eye drops for dry eye and epithelial defects. Clinical and in vitro toxicity studies. BrJophthalmol 2001;85:1188-1197.
- Efficacy of plasma rich in growth factors for the treatment of dry eye. Lopez-Plandolit S, marales MC et. al.
- Begley CG, caffery B, Chalmers RL, et al. Use of dry eye questionnaire to measure symptoms of ocular irritation in patients with aqueous tear deficient dry eye comea, 2002;21:664-670.
- Alio JL, Artola A, symptomatic dry eye treatment with autologous platelet-rich plasma. Ophthalmic Res.2007;39:124-129.
Corresponding Author
Dr Ramakant Thakur
Eye Specialist, Sub-Divisional Hospital, Mahua, Vaishali, Bihar, India