Abstract
Introduction: In the present days, Neonatal encephalopathy is a heterogenous syndrome characterized by signs of central nervous system dysfunction in newborn infants often lead to long lasting detrimental neurological defect.
Material and Method: Prospective type of study was conducted on 150 infants in Obstetrics and Gynecological department of Rajindra Hospital, Patiala and admitted to Neonatology section of Department of Pediatrics with birth asphyxia and were divided into study group (delivered with perinatal asphyxia) and control group (normally delivered without any history of perinatal asphyxia).The data was recorded and subjected to statistical analysis.
Results: It was observed that out of 150 cases of group-I (study group), 87(58%) progressed into Sarnat and Sarnat stage-I had good outcome. 9 (6%) cases progressed into stage-II had poor outcome and 54(36%) in stage-III had poor outcome.
Conclusion: Major cause of morbidity and mortality is birth asphyxia which indicates the need for early detection of maternal risk factors and better obstetric management.
Keywords: neonate, encephalopathy, perinatal, hypoxic.
References
- Hayakawa M, Ito Y, Incidence of prediction of outcome in hypoxic ischemic encephalopathy in Japan, Pediatric international 2014;56: 215-21.
- Dixon BJ, Reis C, Ho WM, Tang J, Zhang JH. Neuroprotective strategies after neonatal hypoxic ischemic encephalopathy. Int J MolSci 2015; 16(9):22368-401.
- Scott H. Outcome of very severe birth asphyxia. Arch Dis Child 1976;51: 712.
- Beken S, Aydin B, Dilli D. Can biochemical markers predict the severity of hypoxic ischemic encephalopathy. The Turkish Journal of Pediatrics 2014;56: 62-68.
- de Vries LS, Jongmans MJ. Long-term outcome after neonatal hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal 2010;95: F220-F24.
- Sekela D Mwakyusa, Manji KP, Massawe AW. The Hypoxic Ischaemic Encephalopathy Score in Predicting Neuro developmental Outcomes among Infants with Birth Asphyxia at the Muhimbili National Hospital, Dar-es-Salaam, Tanzania. Journal of Tropical Pediatrics 2008;55 (1):8-14.
- Abdulqawi K, Yousry Z, Al-Zohairy, Karam K. Early predictors of neuro developmental adverse outcome in term infants with post asphyxia hypoxic ischemic encephalopathy. International Journal of Collaborative Research on Internal Medicine And Public Health 2011: 3 (11):822-37.
- Trotman H., Garbutt A. Predictos of Outcome of Neonates with Hypoxic Ischaemic Encephalopathy Admitted to the Neonatal Unit of the University Hospital of the West Indies. Volume 57, Issue 1, 1 February 2011; 40-44
- Paliwal P, Verma M, Mulye S. Paliwal M, Shaikh MKS. Study of Neurological Marker in Perinatal Asphyxia and its Correlation with Different Stages of Hypoxic Ischemic Encephalopathy. Int J Sci Study 2014; 2(7):40-43.
- Serder Beken, Aydin B, Dilli D. Can biochemical markers predict the severity of hypoxic ischemic encephalopathy.The Turkish Journal of Pediatrics 2014; 56: 62-68
- H Thoker, M. Sheikh, P.A. Thoker. Neuro developmental outcome in perinatal asphyxia. Am J Exp Clin Res 2017; 4(2): 206-09.
- Ellis M., Manandhar N., Manandhar D. S. Risk factors for neonatal encephalopathy in Kathmandu, Nepal, a developing country: unmatched case- control study, 2007; 1229-36.
Corresponding Author
Dr Sandeep Singh
House no. 17, Street no 28-A, Anand Nagar B, Patiala-147001, India
Mob: 9779005767Email: This email address is being protected from spambots. You need JavaScript enabled to view it.