Abstract

Background and Objective: Hyperthyroidism is a common clinical disorder all over world. It occurs at all ages, but is less common before the age of 15 and is an important cause of morbidity in the older age group. Hyperthyroidism is ten times more common in women than men and has a prevalence of 2.5-4.7 per 1000 women. Hyperthyroidism is affecting approximately 2 percent of women and 0.2 percent of men. Even though diagnosis in hyperthyroidism is generally straight forward, its prevalence varies among population.

Methods: Study included 75 patients attending outpatient department (OPD)/admitted in tertiary care Hospital fulfilling the inclusion and exclusion criteria.

Results: Study include 75 patients of hyperthyroidism in which 61 were females and 14 were male patients with female to male ratio of approximately 4.35:1. Incidence of hyperthyroidism is common in the age group between 31 to 40 years. Graves’ disease (76%) was the most common cause of hyperthyroidism, followed by toxic multinodular goiter (18.7%) and toxic adenoma (5.3%). Majority (54.7%) of the patients presented within 12 months of symptom onset. The common clinical manifestations were nervousness (94.7%), increased sweating, heat intolerance and swelling in the neck (90.7%). The commonest signs were goiter (100%), warm skin (90.7%) and tremors (92%).  49.3% of the patients had sinus tachycardia and 9.3% of patients had atrial fibrillation.

Conclusion: Hyperthyroidism was common in the third decade and in females. Graves’ disease was the most common cause of hyperthyroidism. Commonest clinical manifestations were nervousness, increased sweating, heat intolerance and swelling in the neck. Commonest signs were goiter, warm skin and tremors.

Keywords: Hyperthyroidism, Graves’ disease, toxic multinodular goiter, Toxic adenoma.