Abstract
Aims: To evaluate the prescribing pattern among hypertensive patients and analysis these prescriptions to help in improving the quality of care provided.
Methodology: This was a prospective and observational study. Patients of both sex and all age groups those attended the outpatient department (OPD) were included in this study. Acute cerebrovascular accident, acute MI, acute left ventricular failure and pregnant women were excluded from this study.
Results: Out of 350 patients, 193 (55.14%) were male and 157 (44.85%) were female. The average number of drugs prescribed per prescription was 2.52 in our study with a range of 1 to 7. A maximum number of patients (40.86%) were received two antihypertensive drugs followed by single antihypertensive drug (34.85%). CCB was the most common (39.14%) used antihypertensive drugs. Total 138 (39.42%) patients were prescribed fixed-dose drug combination, among this Atenolol + amlodipine FDC was the most commonly used FDC( 40.28%)
Conclusion: Hypertension and its complications can be controlled by diet control, regular exercise, medicines and by time to time follow up. Most commonly prescribed drugs were CCB in this study and ACE inhibitors was most commonly prescribed in diabetic patients. While most common prescribed antihypertensive drug in IHD patients was beta blockers.
Keywords: Prescription Pattern, Antihypertensive drugs, Calcium Channel Blocker, FDC.
References
- Go, AS, Mozaffarian D, Roger VL, American Heart Association Statistics Committee and stroke statistics subcommittee, et. al. Heart Disease and stroke statistics–2014 update: A report from the American Heart Association. Circulation. 2013; 129: e 28–292.
- Third Indian Guidelines on Hypertension ( IGH)- III [ Cited 2013, October 14] Available from : http://www. japi.org/ february _2013_special_ issue_hypertension_ guideline/06_ epidemiology_of_hypertension.html
- Gaziano T, Reddy KS, Paccaud F, Horton S, Chaturvedi V. Cardiovascular disease. In: Jamison DT, Mosley WH, editors. Disease Control Priorities in the Developing World. Oxford: Oxford University Press; 2006. p. 645–62.
- National programme for prevention and control of cancer, diabetes, cardiovascular diseases and stroke ( NPCDCS) Operational Guidelines. Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India.
- 2003 European Society of Hypertension/ European Society of Cardiology Guidelines for the management of arterial hypertension. Journal of Hypertension, 2003, 21; 1011–1053.
- P M From blood pressure to hypertension: the history of research. J of the Royal Soc of Med. 1991; 84:621.
- Rimoy GH, Justin Temu M, Nilay C. Prescribing patterns and cost of Autihypertensive drugs in private hospitals in Dar es Salaam, Tanzanai. East Cent Afr J Pharm Sci. 2008; 11:69–73.
- Kotchen TA. The Search for strategies to control hypertension circulation. 2010; 122:1141–3.
- Dukes MNG. Development from Crooks to the nineties. In: Auditing drug therapy: approaches towards rationality at reasonable costs: proceedings from an international symposium. Stockholm: Swedish Pharmaceutical Press; 1992.
- World Health Organization. Introduction to drug utilization research. Geneva: World Health Organization; 2003.
- Pai PG, Shenoy J, Sanji N. Prescribing patterns of antihypertensive drugs in a South Indian tertiary care hospital. Drug Invention Today: 2011; 3(4), 38-40.
- Etuk E, Isezuo SA, Chika A, AkucheJ, Ali M. Prescription pattern of anti-hypertensive drugs in a tertiary health institution in Nigeria. Annals of African Medicine. 2008; 7(3):128 – 132.
- Adigun AQ, Ishola DA, Akintomide AO, Ajayi AAL.Shifting trends in the pharmacologic treatment of hypertension in a Nigerian tertiary hospital: a realworld evaluation of the efficacy, rationality and pharmaco-economics of old and newer antihypertensive drugs. J Hum Hypertens 2003; 17: 277–285.
- Sandozi T, Emani VK. Survey of prescription pattern of anti-hypertensive drugs in hypertensives & hypertension associated diabetics. International J Pharma and Bio Sciences: 2010; 1(4):23-26.
- Jackson H. James, Sobolski John, Krienke Russ, Wong Ken S., Feride Frech-Tamas, Nightengale Brian, Blood pressure Control and pharmacotherapy patterns in the United States before and after the release of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) Guidelines. J Am Board Fam Med 2008;21:512–21.
- Schoolwerth AC, Sica DA, Ballermann BJ, Wilcox CS: Renal considerations in angiotensin converting enzyme inhibitor therapy: A statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association.Circulation 104:1985-1991, 2001)
- Tripathi KD. Antihypertensive drugs. Essentials of medical pharmacology. 7th ed.. New Delhi: Jaypee; 2013. p. 558-574.
- Bernard MY, Wong YL, Lau CP. Queen Mary Utilization of Antihypertensive Drugs Study(QUADS): use of antihypertensive drug classes in the Hypertension Clinic 1996–2004. Br J Clin Pharmacol. 2005; 60(1):90–97.
- Ahola T. Antihypertensive drug therapy in Finland: Utilization of Antihypertensive Medication, Control of Blood Pressure, and Achievable Reduction of Cardiovascular Morbidity with Intensified Treatment.[ academic dissertation]. Turku: National Institute for Health and Welfare; 2013[ cited 2013, October 15]. Available from : http://www.julkari.fi/ bitstream/ handle 10024/104453/URN_ISBN_978-952-245-862-9.pdf?sequence=1
- Psaty BM, Smith NL, Siscovick DS, et al. Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis. 1997;277:739-45.
- ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA, 2002; 288:2981–2997.
- Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL et al. The eighth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The JNC VIII report. JAMA 2014; 311(5):507–250.
Corresponding Author
Dr Akhtar Ali
Resident, Department of Pharmacology, Dr. S.N. Medical College Jodhpur (Rajasthan), India
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile No- 8058961071
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.195
