Abstract
Background: Leprosy (Hansen’s disease) - a communicable disease still continues to be a social stigma and leading cause of permanent physical disability. This can be prevented by early histopathological diagnosis and adequate treatment accordingly.
Objectives: The aim of the present study was to evaluate the spectrum of different clinico-histopathological categories of leprosy.
Material and Methods: This study was conducted from September 2016 - August 2018, in the Department of Pathology & Skin and Venereal disease on 62 untreated, clinically suspected cases of leprosy.
Statistical Analysis: Descriptive analysis was done in the form of percentage or proportions. P value < 0.05 was considered significant.
Results: In this study 62 cases of leprosy diagnosed as per Ridley-Joplings (R-J) clinical classification were evaluated histopathologically. Most of the cases were seen in young adult males. Majority of cases (42 cases; 67.74%) presented with erythematous lesions and 20 cases (32.25%) presented with hypopigmented lesions. Multiple skin lesions and multiple nerve involvements were commonly seen in lepromatous spectrum. Lepromatous leprosy (LL) was the most common type of leprosy (24 cases; 38.70%) clinically. Indeterminate leprosy (IL) (21 cases; 33.87%) was most common type on histopathological examination. The clinico-histopathological correlation was highest in IL and tuberculoid leprosy cases. Overall correlation was seen in 36 cases (58.06%).
Conclusion: As clinical diagnoses of early leprosy lesions are difficult due to lack of cardinal signs hence biopsy should be done in all cases in order to improve classification and treatment.
Keywords: Clinical, histopathological, leprosy, lesions, spectrum.
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Corresponding Author
Binay Kumar
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile no. 9410713376
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.194
