Title: Clinicopathological profile and molecular characteristics in lung cancer patients in a tertiary care hospital
Authors: Gourab Arun, Nabakishore Sundaray, Soumya Surath Panda, Srikant Kumar Dhar
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.148
Abstract
With rising frequency of different cancer, lung cancer being the commonest one, results in the greater part of the disease related passing over the globe. Malignant growth creates because of oncogene transformation bringing about either loss or gain of function in tumor silencer qualities. This study is useful as it attempts to investigate an area that seek optimum attention in cancer care. The main focus of the study is on the clinicopathological profile and molecular characteristics in patients with lung cancer. The results revealed that out of seven clinical features—lung mass, pleural effusion, cervical lymphadenopathy, bone metastasis, brain metastasis, pneumonia, and other metastasis (scrotum, adrenals)—of the patients, the most prominent one was lung mass (cough, haemoptysis, dysphagia, superior vena cava obstruction, wheezing and stridor, radiological evidence of lung mass with or without symptoms). Of three histopathological types—adenocarcinoma, squamous cell carcinoma, and large cell carcinoma—the most prevalent one was adenocarcinoma in the patients. The EGFR and ALK mutations were common in female patients and in non-smokers with adenocarcinoma. Majority of the patients of adenocarcinoma had lung mass as predominant clinical feature and they also had maximum number of EGFR and ALK mutations. Shortcomings and future directions were also discussed.
Keywords: Malignant, oncogene, adenocarcinoma.
