Abstract

Objective: To Study the efficacy and safety of prior use of mifepristone before misoprostol use in second trimester abortion considerably reduce the induction abortion interval with lowest possible dose and adverse reaction.

Material & Methods: A Prospective Study was conducted which include 50 patients visiting the antenatal OPD elective for  abortions between 13 and 20 week of gestation as per the MTP act. They were randomly divided into two groups of 25 each-the study group received mifepristone 200 mg orally before misoprostol where as the control group was induced with misoprostol alone. The result was analyzed.

Observation: Statistical analysis of the study was done. The induction abortion interval was significantly shorter in the study group, thereby decreasing the side-effect of the drug as well as duration of hospital stay.

Conclusion: This study of offers a reliable, safe and cost effective option by using mifepristone before misoprostol to decrease the induction-abortion interval

Keyword: Mifepristone, Misoprostol, Second Trimester Abortion.