Abstract
A Rare Adult case of Refractory Status Epilepticus with continuous seizures has been brought into ICU. He was treated with multiple anti-epileptics: Phynetoin, midazolam, levetiracetam, dispite of these many anti-epileptics, still seizures were observed in this particular case. By the involvement of clinical pharmacist, dose adjustment of midazolam was done and patient got relieved from the seizures.
Keywords: Status Epilepticus (SE), Refractory Status Epilepticus (RSE), Midazolam, Dose Adjustment, Intensive care unit(ICU).
References
- Kramer U, Chi CS, Lin KL, et al. Febrile infection-related epilepsy syndrome (FIRES): pathogenesis, treatment, and outcome: a multicenter study on 77 children. Epilepsia. 2011;52:1956-1965
- M Holtkamp, J Othman, K Buchheim, H Meierkord Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit J Neurol Neurosurg Psychiatry 2005;76:534–539. doi: 10.1136/jnnp.2004.041947.
- Treiman DM, Meyers PD, Walton NY, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med 1998;339:792–8.
- Misra UK, Kalita J and Dubey D (2017) A Study of Super Refractory Status Epilepticus from India. Front. Neurol. 8:636.
- Ferlisi M, Shorvon S. The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy. Brain. 2012;135:2314-2328
- Shrikiran Aroor1, Kanaparthi Shravan, Suneel C Mundkur. Super-Refractory Status Epilepticus: A Therapeutic Challenge in Paediatrics ,Journal of Clinical and Diagnostic Research. 2017 Aug, Vol-11(8): SR01-SR04
- Nabbout R, Vezzani A, Dulac O, Chiron C. Acute encephalopathy with inflammation-mediated status epilepticus. The Lancet Neurology. 2011;10:99-108.
- Glauser T, Shinnar S, Gloss D, Alldredge B, Arya R, Bainbridge J, et al. Evidence based guideline: treatment of convulsive status epilepticus in children and adults: report of guideline committee of the American epilepsy society. Epilepsy Curr.2016;16(1):48-61
- Micromedex :- Drug-Drug interactions.
- Micromedex :- Drug Information.
Corresponding Author
Dr. C. Nithish
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.74
