Title: HBOT’s effect on Cancer Patients after Radiation Therapy
Authors: Ibrahim A Albrethen, Othman A Alfahad, Mohammad M Alharbi, Thammer S Alhariki, Yahya M Zuhair, Hasna M Hamzi. Salha M Hamzi, Abdulrahman A Alhamzi, Abdulrahman N Almoutairi, Abdulaziz S Almulhem, Faiz M Alruwaili, Abdulrahman F Alharbi
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.37
Abstract
It is widely accepted that radiotherapy that is often used for patients with cancer causes many side-effects in patients. In many cases, these adverse outcomes are closely connected to such patients’ particular problems – the location targeted for treatment, other complications, age, and other factors. Therefore, the treatment of these side effects comes as the next step in a patient’s healing process (Daruwalla & Christophi, 2006). One of the researched and utilized ways of managing the consequences of radiation is hyperbaric oxygen therapy (HBOT). According to Moen and Stuhr (2012), HBOT’s primary purpose is to deal with hypoxia, the condition in which tissues are deprived of oxygen supply. This statement suggests that the oxygen-supplying therapy can help patients with a variety of radiation-induced problems. This review investigates the findings regarding the effectiveness of HBOT on patients who underwent radiotherapy for cancer treatment. The examination covers 12 different studies and focuses on positive and negative outcomes and the potential influence of HBOT on other therapies.
References
- Bem, J., Bem, S., & Singh, A. (2000). Use of hyperbaric oxygen chamber in the management of radiation-related complications of the anorectal region. Diseases of the Colon & Rectum, 43(10), 1435-1438.
- Daruwalla, J., &Christophi, C. (2006). Hyperbaric oxygen therapy for malignancy: A review. World Journal of Surgery, 30(12), 2112-2131.
- Fink, D., Chetty, N., Lehm, J. P., Marsden, D. E., & Hacker, N. F. (2006). Hyperbaric oxygen therapy for delayed radiation injuries in gynecological cancers. International Journal of Gynecological Cancer, 16(2), 638-642.
- Glover, M., Smerdon, G. R., Andreyev, H. J., Benton, B. E., Bothma, P., Firth, O., ... Martin, S. (2016). Hyperbaric oxygen for patients with chronic bowel dysfunction after pelvic radiotherapy (HOT2): A randomised, double-blind, sham-controlled phase 3 trial. The Lancet Oncology, 17(2), 224-233.
- Jones, K., Evans, A. W., Bristow, R. G., & Levin, W. (2006). Treatment of radiation proctitis with hyperbaric oxygen. Radiotherapy and Oncology, 78(1), 91-94.
- Mayer, R., Klemen, H., Quehenberger, F., Sankin, O., Mayer, E., Hackl, A., & Smolle-Juettner, F. M. (2001). Hyperbaric oxygen–an effective tool to treat radiation morbidity in prostate cancer. Radiotherapy and Oncology, 61(2), 151-156.
- Moen, I., &Stuhr, L. E. (2012). Hyperbaric oxygen therapy and cancer—A review. Targeted Oncology, 7(4), 233-242.
- Oscarsson, N., Arnell, P., Lodding, P., Ricksten, S. E., & Seeman-Lodding, H. (2013). Hyperbaric oxygen treatment in radiation-induced cystitis and proctitis: a prospective cohort study on patient-perceived quality of recovery. International Journal of Radiation Oncology, Biology, and Physics, 87(4), 670-675.
- Safra, T., Gutman, G., Fishlev, G., Soyfer, V., Gall, N., Lessing, J. B., ... Grisaru, D. (2008). Improved quality of life with hyperbaric oxygen therapy in patients with persistent pelvic radiation-induced toxicity. Clinical Oncology, 20(4), 284-287.
- Stępień, K., Ostrowski, R. P., &Matyja, E. (2016). Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours. Medical Oncology, 33, 101.
- Sultan, A., Hanna, G. J., Margalit, D. N., Chau, N., Goguen, L. A., Marty, F. M., ... Tishler, R. B. (2017). The use of hyperbaric oxygen for the prevention and management of osteoradionecrosis of the jaw: A Dana‐Farber/Brigham and Women's Cancer Center multidisciplinary guideline. The Oncologist, 22(3), 343-350.
- Teguh, D. N., Levendag, P. C., Noever, I., Voet, P., van der Est, H., van Rooij, P., ... Schmitz, P. I. (2009). Early hyperbaric oxygen therapy for reducing radiotherapy side effects: Early results of a randomized trial in oropharyngeal and nasopharyngeal cancer. International Journal of Radiation Oncology, Biology, and Physics, 75(3), 711-716.
- Wilkinson, D., &Doolette, D. (2004). Hyperbaric oxygen treatment and survival from necrotizing soft tissue infection. Archives of Surgery, 139(12), 1339-1345.
Corresponding Author
Ibrahim A Albrethen
