Abstract
Background: Hypothyroidism is one of the most common and treatable endocrine disease in which there is insufficient amount of thyroid hormones in body. Iodine deficiency remains the most common cause of hypothyroidism worldwide. The food grown in soil of hilly areas and around rivers is iodine deficient due to leaching out of iodine from soil, resulting in increased incidence of hypothyroidism in these areas.
Objective: To estimate the prevalence of hypothyroidism in adults in Kashmir valley
Methodology: This cross-sectional study was conducted in Kashmir valley. Kashmir valley was divided into three zones. North south and central zones to study the prevalence of hypothrodism among adult population of Kashmir valley. Hypothyroidism was diagnosed as elevated TSH with normal or low T4.
Results: A total of 4770 adults with more than 20 years of age were studied for hypothyroidism of which 2130 were males and 2640 were females. The overall prevalence of hypothyroidism was found to be 16.18 per cent. Prevalence of hypothyroidism was more among rural population (18.45 %) as compared to urban population (11.63%).Prevalence of hypothyroidism was more as age of patients increased.It was more among females than males.
Conclusion: Hypothyroidism is a growing problem in this part of world. It is more common in rural than in urban, more common among females as compared to males. This high prevalence of Hypothyroidism is a cause of concern since it is a multisystem disorder and is associated with profound morbidity and mortality
References
- Ganong WF. Review of Medical Physiology. 22nd Edition Singapore: McGraw Hill 2005; p 317-32
- Kapil U. Sohal KS. Sharma TD. Tandon M. Assessment of Iodine Deficiency Disorders using the 30 cluster approach in district kangra Himachal Pardesh, Indian J Trop Pediatr 2000; 46: 264-6.
- Dayan CM, Daniels GH. Chronic autoimmune thyroiditis. N Engl Med 1996; 335:99-107.
- Pearce EN, Farwell AP, Braveman LE. Thyroiditis. NEngl J Med 2003; 348:2646-55.
- Jameson LL, Weetman AP. Disorders of the Thyroid Gland. Harrison’s Principle of Internal Med. 17th Edition, 2005; 335;224-2247.
- Unachak, Dejkhamron P. Primary Congenital Hypthroidism: Clinical characteristics and etiological study. J. Med Assoc Thai 2004; 37: 642-7.
- Tunbrodge WM, Hall R, Appleton D, Brewis M, Clark F,et al. The spectrum of thyroid disease in a community: the Whicham Survey. ClinEndocrinol (Oxf). 1977 Dec; 7 (6): 481-493.
- Aoki Y, Belin RM, Clickner R, Jeffries R, Philips I, Mahaffey KR Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999-2002). Thyroid, Dec 2007; 17(12):1211-23.
- Baral N, Lamsal M, Komer BC, Koirala S. Thyroid Dysfunction in Eastern Nepal. South East Asian J Trop Med public health 2002;33(3):638-41.
- Canaris GJ, Neil R, Manowitz, Gilbert Mayer, Chester Ridgway. The Colorado Thyroid Disease Prevalence Study. Arch Intern Med. 2000; 160:526-534.
- Ray A, Biswas U, Mukherjee A, Sarker KC, SamajdarK and Mukherjee G. Assessment of Iodine and Non-Iodine Deficiency Hypothyroidism in women of Reproductive ages in Sub-Himalayan plains of West Bengal Indian J PhysiolPhymacol 2009;53(4):359-364.
- Krysiak R, Okopien B, Hermen ZS. Subclinical thyroid disorders. Pol MerkurLekarski, 2006;21:573-578.
- Galofre JC, Garcia-Mayor RV, Fluiters E, Fernandes-Calvet L, RegoA, Paramo C, et al. Incidence of different forms of thyroid dysfunction and its degrees in an iodine-sufficient area. Thyroidology. 1994;6:49-54.
- Hollowell JG, Staehlin NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T4 and thyroid antibodies in the United states Population (1988 to 1994): The National Health and Nutritional Examination Survey (NHANES III). J ClinEndocrinolMetab. 2002;87:489-499.
- Raterman HG, van Halm VP, Voskuyl AE, Simsek S, Dijkmans BAC and Nurmohamed MT. Rheumatoid arthritis is associated with a high prevalence of hypothyroidism that amplifies its cardiovascular risk. Annals of the Rheumatic Disease 2008; 67:229-232
- Vaderpump MPJ, Tunbirdge WMG. The epidemiology of thyroid diseases. In: Braverman LE, Utiger RD, eds. Werner and Inagbar’s the thyroid. Philadelphia: Lippincott-Raven; 2000:467-473.
- Eggersten R, Petersen K, Lundberg PA, Nystrom E, Lindstedt G. Screening for thyroid disease in a primary care unit with a thyroid stimulating hormone assay with a low detection limit. BMJ, 1988; 297:1586-1592.
- Sawin CT, Chopra D, Azizi F, Mannix JC, Bacharach P. The aging thyroid: Increased prevalence of elevated serum thyrotropin levels in the elderly. JAMA 1979; 242(3): 247-250.
- Sawin CT, Castelli WP, Hershman JM, McNamara P, Bacharach P. The aging thyroid: thyroid deficiency in the Framingham study, Arch Intern Med. 1985; 145: 1386-1388.
- Okamura K, Ueda K, Sone H, et al. A sensitive thyroid stimulation hormone assay for screening of thyroid functional disorder in elderly Japanese. J Am Geriatr. Soc. 1989; 37:317-322.
- Livingston EH, Hershman JM, Sawin CT, Yoshikawa TT. Prevalance of thyroid disease and abnormal thyroid tests in older hospitilised and ambulatory persons. I am Geriatr Soc. 1987; 35:109-114.
- Konno N, Makita H, Yuri K, LIzuka N, Kawasaki K Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the regions of Japan. J ClinEndocrinolMetab 1994;78:393-397.
- Vanderpump MP, Tunbridge WM, French JM et al. The incidence of thyroid disorders in the community: a twenty- year follow-up of the Wickham Survey. ClinEndocrinol 1995;43(1):55-68.
- Wang C, Crapo LM. The epidemiology of thyroid diseases and implications for screening. EndocrinolMetabClin North Am 1997;26:180-218.
- Launberg P, Balow PI, Pederson KM, et al. Low incidence rate of overt hypothyroidism compared with hyperthyroidism in an area with moderately low iodine intake. Thyroid. 1999;9:80-88.
- Flyn RW, Mac Donald TM, Morris AD, et al. The thyroid epidemiology, audit, and research study: thyroid dysfunction in the general population. J ClinEndocrinol 2004; 89:3879-84.
Corresponding Author
Dr Peerzada Mohammad Shafi
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Cell: +91-9797859030