Abstract
Background: Pulmonary function tests are of prime importance in the diagnosis and prognosis of a large number of respiratory disorders. Normative values of lung functions of healthy population are affected by multitude of factors like geographic, ethnic, climatic and demographic factors. So it is essential to have a reference value of the sample population to prevent under diagnosis and over diagnosis of any disease.
Objectives: Present study was designed to derive normative values of spirometric indices, forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1), FEV1 as a percentage of FVC (FEV1%), mid expiratory flow rate (FEF25-75%) and peak expiratory flow rate (PEFR) in both sexes.
Material and Methods: Pulmonary function tests were carried out in a total of 160 non- smoking healthy adult subjects, of age group between 21-60yrs. 80 each of them were from opposite sex
Results and Conclusion: Values of the above spirometric parameters were obtained which were comparable with that of other South Indian studies. Male sex had higher spirometric values compared to female sex except for FEV1/FVC ratio. The differences in all parameters FEV1/FVC ratio were statically significant. These values may be used as reference values in this geographical area.
Keywords: FVC, FEV1, FEV1/FVC, FEF, PEFR, sex.
References
- Woolcock JA, Colman MH BC. Factors affecting normal values for ventilatory lung function. Am Rev Respir Dis. 1972;106:692–709.
- Roca J, Sanchis J, Agusti-Vidal A, Segarra F, Navajas D, Rodriguez-Roisin R et al. Spirometric reference values from a Mediterranean population. Bull Eur Physiopathol Resp. 1986;22:217–24.
- Oxhoj H, Jeppesen GM, Larsen VH JB. Spirometry in healthy adult never-smokers. Clin Physiol. 1988;8:329–39.
- Dockery DW, Ware JH FB. Distribution of forced expiratory volume in one second and forced vital capacity in healthy, white, adult never-smokers in six US cities. Am Rev Resp Dis. 1985;131:511–20.
- Bandyopadhyay A, Basak AK, Tripathy S BP. Peak expiratory flow rate in female brick-field workers of West Bengal, India. Ergon SA. 2006;18:22–7.
- Chatterjee S, Saha D CB. Pulmonary function studies in healthy non-smoking men of Calcutta. Ann Hum Biol. 1988;15:365–74.
- Rao MN, Gupta AS, Saha PN DS. Physiological norms in Indians: Pulmonary capacities in health. ICMR Spec Report New Delhi Indian Counc Med Res. 1961;38.
- Da Costa JL. Pulmonary function studies in healthy Chinese adults in Singapore. Am Rev Respir Dis. 1971;104:128–31.
- Johannsen ZM EL. Clinical spirometry in normal Bantu. Am Rev Respir Dis. 1968;97:585–97.
- Dufétel P, Pigearias B, Lonsdorfer J, Derossi GC, Diaine C FP. Spirometric reference values in Senegalese black adults. Eur Respir J. 1989;2:252–8.
- Bandyopadhyay A. Pulmonary function studies in young healthy Malaysians of Kelantan, Malaysia. Indian J Med Res. 2011;134:653–7.
- Chen H I KCS. Relationship between respiratory muscle function and age, sex, and other factors. J Appl Physiol. 1989;66(2):943–8.
- Bellemare F1, Jeanneret A CJ. Sex differences in thoracic dimensions and configuration. Am J Respir Crit Care Med. 2003;168(3):305–12.
- Martin TR, Castile RG, Fredberg JJ, Wohl ME MJ. Airway size is related to sex but not lung size in normal adults. J Appl Physiol. 1987;63(5):2042–7.
- Michelle A. Carey, Jeffrey W. Card, James W. Voltz, Samuel J. Arbes, Jr, Dori R. Germolec, Kenneth S. Korach and DCZ. It’s all about sex: male-female differences in lung development and disease. Trends Endocrinol Metab. 2007;18(8):308–13.
- Baig MIA and RHQ. Pulmonary function tests: Normal values in non-smoking students and staff Aga Khan University, Karachi. JCPSP. 2007;17(5):265–8.
- Saxena Y, V Saxena JD and RKS. Evaluation of dynamic function tests in normal obese individuals. Indian J Physiol Pharmacol,. 2008;52(4):375–382.
- Soundariya K, Neelambikai N. BMI, Waist Circumference and PFT - Influence of Anthropometric Indices on Pulmonary Function Tests in Young Individuals . 2013;9(3):157–61.
- Rao NMN, Mavlankar MO, Kulkarni PK, Ap SKK. Pulmonary function studies in Gujarati subjects. Indian J Physiol Pharmacol. 1992;36(1):55–9.
Corresponding Author
Jowhara. P.V
Additional Professor, Department of Physiology, Government Medical College, Kozhikode, Kerala, India
Mob: 8547354578, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v6i12.119
