Abstract
Objective: To evaluate carotid intima media thickness as a preclinical atherosclerosis marker in diabetic marker in diabetic patients.
Method: The study was conducted in PG Department of Medicine in Cardiology Unit, SN Medical College, Agra, Patients of any age group willing to take part in the study were included. Determination of Carotid intima media thickness (CIMT) was done by standard USG machine with high frequency probe.
Results: In our study the mean duration of diabetes was 5.7 years with SD of 4. The mean CIMT in patients with diabetes of less than 5yrs (n=23) was 0.78 with SD of 0.07, while the mean CIMT in patients who have diabetes for more than 5 yrs is 0.87mm with SD 0.003. Using t test to compare the two groups, the p value was less than 0.001. This shows the impact of duration of diabetes with carotid intima media thickness and hence risk for atherosclerosis complication. Some patients in our study have short duration of diabetes but have high CIMT value which may be due to the late detection of diabetes.
Conclusion: CIMT measurements is an effective , noninvasive tool which can assist in identifying people with diabetes who are at higher risk of developing microvascular and macrovascular complications. It may also help to effectiveness of various treatment strategies used to treat people with diabetes.
Keywords: B-Mode USG,CIMT, Atherosclerosis, Diabetes.
References
- Abbott RD, Donahue RP, Kannel WB, Wilson PW. The impact of diabetes on survival following myocardial infarction in men vs women. The Framingham Study. JAMA. 1988;260(23):3456–3460.
- Gu K, Cowie CC, Harris MI. Mortality in adults with and without diabetes in a national cohort of the US population, 1971–1993. Diabetes Care. 1998;21(7): 1138–1145.
- Savage PJ. Cardiovascular complications of diabetes mellitus: what we know and what we need to know about their prevention. Ann Intern Med. 1996;124(1 Pt 2):123–126.
- Webster MW, Scott RS. What cardiologists need to know about diabetes. Lancet. 1997;350 Suppl 1:SI23–SI28.
- Stamler J, Vaccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care. 1993;16(2): 434–444.
- Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979;241(19):2035–2038.
- Jude EB, Oyibo SO, Chalmers N, Boulton AJ. Peripheral arterial disease in diabetic and nondiabetic patients: a comparison of severity and outcome. Diabetes Care. 2001;24(8):1433–1437.
- O’Leary DH, Bots ML. Imaging of atherosclerosis: carotid intima-media thickness. Eur Heart J. 2010;31(14):1682–1689.
- McGarry PA, McMohan CA, Montenegro MR et al. General findings of the International Atherosclerosis Project. Lab Invest 1968;18:498-502.
- Iglesias del Sol A, Bots ML, Grobbee DE, Hofman A, Witteman JC. Carotid intima-media thickness at different sites: relation to incident myocardial infarction; The Rotterdam Study. Eur Heart J. 2002;23(12): 934–940.
- Kochupillai N. Clinical Endocrinology in India. Current-Sci 2000;79:1061-1067.
- Won Sang Yoo, Hee Jin Kim et al. “Early Detection of Asymptomatic Coronary Artery Disease in Patients with Type 2 Diabetes mellitus” Korean J Intern Med 2009; 24(3): 183-189.
Corresponding Author
Dr Kushal Pal
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mob: 9690795611
DOI: https://dx.doi.org/10.18535/jmscr/v6i12.115
