Abstract
Aim and Objectives: Discuss relevant laboratory findings raised PDW with age and sex distribution. Establish care guidelines for HIV infected person and altered haematopoiesis resulting in with raised red cell distribution width. Review the pathogenesis of the haematological manifestations of human immunodeficiency virus (HIV).
Method: Blood was collected in a sterile EDTA containing tube and processed following our established laboratory protocol and by universal precaution as per the guideline of National aids control organization (NACO, India). A complete blood counting including HB%, PCV, Red cell indices, platelet count, Red cell distribution width and total white cell count and differential was done by Automated blood cell counter analyzer of all the patient on antiretroviral therapy .The all cell count indices including WBC count with differential and platelet count, was further confirmed by manual oil immersion smear study method. Peripheral smears study was done with field A and B Stain and Leishman stain.
Result: In our study out of 300 HIV cases 189 cases (63%, n=300) shows increased PDW in which male cases are 125 cases (66.48%, n=188) and female cases are 64 (57.14%, N=112).
Conclusion: PDW is commonly affected haematological parameter in HIV infective cases. higher red blood cell distribution width is associated with a worse virologic and clinical situation in HIV infected.
References
- Rosario Palalios et al. In “Red cell distribution width in patient with HIV infection” at Spain in infectious disease unit of virgin Dela Victoria Hospital, Malaga during 2007 (sample size all HIV positive cases under follow-up testing) (Journal of Internal Medicine 2012 vol. 2 page 7-1
- Sanchez - Chaparro MA. et al. In “high red cell distribution width is associated with the metabolic syndrome” (J. Diabetes care 2010 (1) pp 33-40.
- Abdel-Monem H, Prakasam A, Thiagarajan P. Howell- Jolly Body-like Inclusions in neutrophils of transplant recipient in association with ganciclovir Arch Pathol Lab Med 2010;134:809–10.
- Ajay Wanchu et al. in the “profile of heamatological abnormality of Indian HIV infected individual” in PGI Chandigarh over a period of 2 years from 2007-09 India when sample size n=200. In this study also show anaemia is most common hematological finding in HIV positive cases. (BMC blood disorders 2009, 9:5doi:10-1186/1417-2325-9-5
- Albini A, Barillari G, Benelli R et al: Angiogenic properties of human immunodeficiency virus type 1 Tat protein. Proc Natl Acad Sci USA 92:4838, 1995
- Amballi AA et al. in retrospective study of “Demographic pattern and haematological profile in people living with HIV /Aids” in a University Teaching Hospital Sagamu, Ogun State over a five years period of time from 2000 to 2005. [Scientific Research and Essay vol. 2 (8) pp v 315-318 August 2007) (Sample size n=162)]
- Attili SVS et al. “Hematological profile of HIV patient in relation of immune status a hospital based cohort study” from Varanasi North India (Turk. J. Hematol. 2008 vol. 25 13-19.
- Baillieres best tract res clinical heamotol 2000 June 13 (2) : 215-30. “Hematological aspect of HIV infection.” Evans RH Scadden DT, Harvard Medical School, Boston USA.
- Barbara J. Bain et al. –“ The haematological features of HIV infection” at Department of haematology, St. Marry Hospital Campus of Imperial College, London (American J. Of Haematology, 2008;( 83):738)
- Daniel Nii Aryee Tagoe et al in a case control study of " profiling hematological changes in HIV patient attending fevers clinic” at the central regional hospital in Cape Coast Ghana , over a six month period when sample size n=150 ( Archives of APPLIED SCIENCE RESEARCH ,2011,3(5) 326-33
- Deepak Arora in the “longitudinal changes in hematological manifestation of HIV infection in the multicentre AIDS cohort study in department of microbiology Adesh Institute of Medical Science and Research Bathinda” over a 2 year period of time from 2007 to 2009. [Biomedical research 2011, 22(1):103-106].
- Dysplastic neutrophils with the reference of study of brain B.J. (American Journal of haematol 83.738) and Baillieres best et al (Jour. Pract. Res. Clin Haematol 200 Jun 13 (2) 215-30)
- Kasthuri AS et al. in a study of “hematological manifestation of HIV infection at HIV tertiary care” center over a period time March 1998 to August 1999. Majority was in patient and a few outpatients Bangalore. Sample size (n=100) HIV infected patient. Indian Journal sex transmission disease 2006 vol. 27 No. 1-9.
- Mocroft A. et al. anaemia is an independent predictive marker for clinical prognosis in HIV infected patient from across Europe, Euro SIDA study group (AIDS 1999; (28):943-50.)
- R. Palacios et al. In “higher red blood cell distribution width is associated with a worse virologic and clinical situation in HIV infected patient in observational cross sectional study” (Journal Int AIDS Soc. 2010:13
- Robertson DL, Hahn BH, Sharp PM. (1995). "Recombination in AIDS viruses". J Mol Evol. 40 (3): 249–59. doi:10.1007/BF00163230. PMID 7723052.
Corresponding Author
Dr Sachin Sharma
Assistant Professor, MGM Medical College with M.Y. Hospital Indore, MP, India
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v6i11.152
