Abstract
Objective: To estimate serum calcium, phosphorus and magnesium in hypothyroidism and to compare the same in normal thyroid function.
Materials and Methods: The study involved 35 controls with normal thyroid function and 35 subjects with hypothyroidism, of age group 20-45 years. The serum samples were analyzed for parameters and their respective methods.
Result: Serum calcium was found decreased and serum phosphorus was increased in hypothyroidism. The study also showed a relatively lower magnesium levels among the hypothyroid patients.
Conclusion: The study underlines the necessity for patients with hypothyroidism to be monitored for mineral status to avoid the respective complications.
Keywords: Calcium, phosphorus, magnesium, hypothyroidism.
References
- Kochupillai N. Clinical endocrinology in India. Current science, vol. 79, No. 8,25 October 2000.
- Velayutham K et al. Prevalence of thyroid dysfunction among young females in a South Indian population. Indian Journal of Endocrinology and Metabolism 2015:19(6):781-784.
- Sato K et al. Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells through triiodothyronine nuclear receptors. Endocrinology 1987;120(5):1873-81.
- Kavitha M M et al. Evaluation of serum electrolytes in hypothyroid patients. Med Pulse – International Medical Journal August 2014;1(8):393-395.
- Arvind Bharti et al. Assessment of serum minerals and electrolytes in thyroid patients IJASR VOL 01;ISSUE 06;2015:259-263.
- Murgod R, Soans G. Changes in Electrolyte and Lipid profile in Hypothyroidism. International Journal of Life science and Pharma research 2012;2(3):185-194.
- William’s text book of endocrinology, Chapter 11.
- Suneel B, Nagendra DR, Aparna RR, Balakrishna D, Naidu JN. Mineral status in thyroid disorders (Hypo and Hyper). International journal of applied biology and pharmaceutical technology (IJABPT) 2011;2(4):423-429.
- Huerta MG et al. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes care.2005;28:1175-81.
- Hussein Kadhem Al-Hakeim. Serum Levels of Lipids,Calcium and Magnesium in Women with Hypothyroidism and Cardiovascular Diseases. J Lab Physicians.2009;1(2):49–52.
- Roopa M, Gladys S. Changes in electrolyte and lipid profile in hypothyroidism. International journal of life science and pharma research 2012;2(3);L185-194.
- Jaskiran K, Naved A, Akash G. Changes in the Electrolyte Profile of Patients having hypothyroidism. Journal of medical science and clinical research (JMSCR) 2014;2(4):633-637.
- Abbas MM, Mahmoud AH and El-Desouky W. Biochemical Changes in Serum Lipid Fractions, Calcium, Magnesium and Phosphorous Levels in Women with Subclinical Hypothyroidism. Nature and Science 2013;11(5):113-118.
- Alcalde AI, Sarasa M, Raldua D, Aramayona J, Morales R, Biber J. Role of thyroid hormone in regulation of renal phosphate transport in young and aged rats. Endocrinology 1999;140(4):1544– 51.
- Schwarz C, Alexander BL, Spiros A, Georg MF, Heinz Z, Aristomenis KE, Gregor L. Thyroid function and serum electrolytes: does an association really exist?. Swiss Med. Wkly 2012;142:w136.
- Mane AY, Bhagwat VR. Assessment of some biochemical markers of bone turnover in thyroid dysfunction state. International Journal of Pharma and Bio Sciences 2012;3(3): B126 –133.
- Shivaleela MB, Poornima RT and Jayaprakash MDS. Serum Calcium and Phosphorus levels in thyroid dysfunction. Indian Journal of Fundamental and Applied Life Sciences 2012;2(2):179-183.
- Begic-Karup KS et al. Serum calcium in thyroid disease. Wein Klin Wochenschr 2001;113(1-2):65-8.
Corresponding Author
Dr B. Gayathri
Assistant Professor, Department of Biochemistry, SRM Medical College Hospital & Research Centre,
SRM IST, Kattankulathur, Kanchipuram district, Tamilnadu, India
Phone: +91 94884 51198, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v6i11.66
