Title: Assessment of efficacy of Topical ofloxacin compared with gentamicin in the treatment of external ocular infection: a comparative study
Authors: Dr Niladri Saha MBBS (Cal), DO(Cal), MS (Cal), Dr Nilotpal Saha MBBS
DOI: https://dx.doi.org/10.18535/jmscr/v6i11.49
Abstract
Background: External ocular infection can be bacterial, viral, or fungal. Viral ocular infections are often self-limiting. Therapy may reduce symptoms but does not affect the clinical course of viral external ocular infection. Hence; we planned the present study to compare the efficacy of topical ofloxacin compared with gentamicin in the treatment of external ocular infection.
Materials and Methods: The study was conducted in the Department of Ophthalmology of the MGM MEDICAL College and LSK Hospital, Kisanganj, from July 2016 -July 2017. For the study, a total of 100 patients with suspected external ocular bacterial infection were selected. A detailed informed consent was obtained from the patients. The patients were randomly grouped into two groups, Group 1 and Group 2. Subjects in group 1 were given topical Ofloxacin for application on the eye with external ocular infection. Subjects in group 2 were given topical Gentamicin for application on the eye with external ocular infection.
Results: There were total of 50 patients in each group. Number of male patients in group 1 was 32 and in group 2 was 35. Number of female patients in group 1 was 18 and in group 2 was 15. The mean age of patients in group 1 was 42.82 years and in group 2 was 51.33 years. In group 1, clinical improvement was seen in 42 patients and microbiological improvement was noticed in 40 patients. In group 2, clinical improvement was seen in 45 patients and microbiological improvement was noticed in 42 patients.
Conclusion: From the results of present study, we conclude that topical Ofloxacin and Gentamicin are both equally efficacious in treatment of external ocular infection.
Keywords: External ocular, internal ocular, bacterial infection, Ofloxacin.
