Abstract
Background: Leukocyte counts are frequently done investigation in new born babies especially when neonatal sepsis is suspected. About one third of newborn babies were born as preterm in India and neonatal sepsis is a important cause of mortality and morbidity in neonatal period.
Objective: This study was undertaken to establish the reference values for various leukocyte counts among term and preterm babies and to compare the values each other to find out any significant difference.
Materials and Methods: Umbilical cord blood samples were taken from 140 babies, 70 of them belongs to each group. Leukocyte counts were detected. The data obtained was analyzed with SPSS version 16.
Results and Conclusion: Present study revealed a statically significant decrease in TLC as gestational age increases. ANC had a direct relationship with gestational age, as gestational age increases ANC increases. ALC had an inverse relationship with gestational age, which decreases as gestational age advances. The normal range for TC and ANC were significantly different in both groups. The reference value obtained can be used as background data for early identification and management of neonatal sepsis.
Keywords: total leukocyte count, differential count, absolute neutrophil count. term, preterm.
References
- Stoll JB, Kliegman: The high risk infant. Nelson Textbook of paediatrics. Philadelphia, WB Saunder Company. 2004.5472-5450p
- SS, Basyal B, Wagle K, et al. (2015) Low Birth Weight at Term and Its Determinants
- in a Tertiary Hospital of Nepal: A Case-Control Study. PLoS ONE: e0123962 doi:10.1371/ journal.pone.0123962.
- Singh M.Care of the newborn. sagar publication. 4th edition,1991;p112,120
- Microsoft Word - Nnpd report for pdf.doc - nnpd_report_2002-03.PDF. Available at http://www.newbornwhocc.org/pdf/nnpd_report_20 02-03.PDF. Accessed on 2017 Apr 29.
- Darmstadt GL, Bhutta ZA, Cousens S, Adam T, Walker N, de Bernis L. Lancet Neonatal Survival Steering Team. Evidence based, cost effective interven-tions: How many newborn babies can we save? Lancet. 2005;365(9463):977-88.
- Muthukumaran N. Mortality profile of neonatal deaths and deaths due to neonatal sepsis .Int J Contemp Pediatr. 2018 Jul;5(4):1583-1587
- Forestier F et al: Developmental erythropoiesis in normal human fetal blood. Blood.77:2360, 1991
- Forestier F et al. Hematological values of 163 normal fetuses between 18 to 30 weeks of gestation. Pediatr Res. 20:342.1985
- Murutosky J et al. Hamatological values in fetal blood by cordocentesis. Nipon Sanka Fujinija Gakkai Zasshi.1992 june: 44(6):638-42
- Marwaha N et al.Routine hematological values in term newborns. Indian Pediatr.29(9):1095-9,1992 Sep
- Stallmach R, Karolyi L. Augmentation of fetal granulopoiesis with chorioamnitis during second trimester of gestation. Hum Pathol 25:244,1944.
Corresponding Author
Ashraf.T.P
Additional Professor, Department of Pediatrics, Government Medical College, Kozhikode, India
Mob: 9895324551, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v6i11.26
