Abstract
Introduction: Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. The inflammatory response can lead to decreased corneal sensation, scarring, and blindness. So accurate diagnosis is necessary for proper treatment, in order to prevent serious consequences.
Methodology: This was a retrospective study documenting the clinical profile and outcome of herpetic keratitis treated in a hospital in North Indian State.
Results: An aggregate of 200 patients were determined to have herpetic keratitis. Most common presentation was dendritic ulcer, followed by stromal keratitis and geographical ulcer. Most frequent associated ocular lesion with keratitis was conjunctivitis followed by uveitis and lid involvement. Among 200 cases, 120 cases (60%) were males & 80 (40%) were females. Right eye was involved in 120 (60%) and left eye in 80 cases (40%). The age distribution and majority of Patients 72(36%) are in the age group of 30-40. Visual acuity was grossly reduced <or = 6/60 in majority of patients with stromal disease (93.8%) while majority of patients with epithelial disease (88.89%) had visual acuity > 6/60. 57 (63.3%) had complete resolution in ist week & rest 33(36.7%) took 2 weeks for complete resolution. 64.5% had complete resolution after treatment & only 5% had visually significant residual disease.
Keywords: cornea; herpes simplex virus; herpetic stromal keratitis.
References
- Darougar S, Wishart MS, Viswalingam ND; Epidemiological and clinical features of primary herpes simplex virus ocular infection. Br J Ophthalmol. 1985; 69 (1):2-6.
- Rolinski J, Hus I; Immunological aspects of acute and recurrent herpes simplex keratitis. J Immunol Res. 2014; 2014:513560.
- Kaufman HE, Azcuy AM, Varnell ED, Sloop GD, Thompson HW, Hill JM; HSV-1 DNA in tears and saliva of normal adults. Invest Ophthalmol Vis Sci. 2005; 46 (1):241-7.
- Suveges I, Fust A, Imre L; Postoperative therapy after penetrating keratoplasty in herpes simplex keratitis. ORV Hetil.2013; 154 (52):2065-70.
- Zarei-Ghanavati S, Alizadeh R, Yoo SH; Herpes Simplex Virus Endotheliitis following Descemet's Membrane Endothelial Keratoplasty. J Ophthalmic Vis Res. 2015;10 (2):184-6
- Yin D, Huang A, Warrow D, Ritterband DC, Seedor JA, McCormick SA, et al.; Detection of herpes simplex virus type 1 in failed descemet stripping automated endothelial keratoplasty grafts. Cornea. 2013; 32 (9):1189-92.
- Perng GC, Osorio N, Jiang X, Geertsema R, Hsiang C, Brown D, et al.; Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. Curr Eye Res. 2016; 41 (3):284-91.
- Liesegang TJ; Herpes simplex virus epidemiology and ocular importance. Cornea. 2001; 20 (1):1-13.
- Labetoulle M, Auquier P, Conrad H, et al. Incidence of herpes simplex virus keratitis in France. Ophthalmology. 2005;112:888–895. [PubMed]
- Uchio E, Hatano H, Mitsui K, et al. A retrospective study of herpes simplex keratitis over the last 30 years. Jpn J Ophthalmol. 1994;38:196–201. [PubMed]
- Kaiser man I, Kaiserman N, Nakar S, Vinker S; Herpetic eye disease in diabetic patients. Ophthalmology. 2005; 112 (12):2184-8.
- Du T, Zhou G, Roizman B; Induction of apoptosis accelerates reactivation of latent HSV-1 in ganglionic organ cultures and replication in cell cultures. ProcNatlAcadSci U S A.2012; 109 (36):14616-21.
- Souza PM, Holland EJ, Huang AJ; Bilateral herpetic keratoconjunctivitis. Ophthalmology. 2003; 110 (3):493-6.
- Raju KV, Jyoti, P.T., Shimna I; Clinical Profile of Herpes Simplex Keratitis. Kerala J Ophthalmol. 2001;1 ([33):7.
Corresponding Author
Dr Mohd Yousuf
Senior Consultant Ophthalmologist, JK Health Services
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.