Abstract

Background: Thalassemia is the most common hereditary anemia in human. The most common types of disease are the alpha and beta thalassemia, Thalassaemia are important challenges for tribal populations in Rajasthan. Thalassaemia genes are variably distributed across various tribal populations of Rajasthan. The morbidity varies greatly in different areas of the country due to differential co-inheritance of α-thalassaemia gene and interaction of various epistatic and environmental factors. Though substantial data on prevalence of these disorders exist, there is an urgent need to develop integrated hierarchical core facilities to manage the disease. Newborn screening, genetic counselling, carrier detection, prenatal diagnosis along with management of cases should form the basic infrastructure of thalessemia management. Research in this area should continue focusing on various challenges in care delivery, prevention and basic sciences on interaction of thalessemia with various other infections.

Aim of study: To determine serum levels of the Calcium, Phosphorus in thalassemic patients.

Material and Methods: The present study sample was collected from the thalassemia care centre in MB Hospital Udaipur and the test was performed in the Central Biochemistry laboratory of Pacific Medical College & Hospital. The Study Design is Prospective Cross Sectional Study. The study done between March 2018 to September 2018. We divide our 40 samples into 20 cases and 20 as control group.  

Statistical Analysis: for statistical analysis independent t-test and Pearson correlation test was used.

Result: Maximum no. of patients 15 (75%) belonged to 4-10 years of age group I. Only 5(25% of cases) belonged to 11-14 years of age group II. In thalessemic patients mean serum calcium level is 7.47±0.11 and control group mean serum calcium level is 9.43±0.11 which is significantly (p value <0.001) Mean phosphorus level in Thalassemic patients is 5.310±0.10 and 3.98±0.10 in control group

Conclusion: β- thalassemia is the commonest single-gene disorder in the Indian population 10. 10% of the total world thalassemics are born in India every year11. In our study demonstrate that significantly reduced level of serum calcium, and high phosphorus level in children with thalassemia belong to age group 11-14 years as compared to 4-10 years of age group.

Keywords: Calcium, Phosphorus, Thalassemia.