Title: Prevalence of urinary tract pathogen and its antimicrobial susceptibility pattern in children admitted in KMCH, Katihar, Bihar and compare its susceptibility pattern from national trend
Authors: Ashit Kumar, Ghazi S. Ahmad, Kumar S. Nath, Shreshy Singh, MD Arshad Alam
DOI: https://dx.doi.org/10.18535/jmscr/v6i10.158
Abstract
Objective: This study was conducted to determine the prevalence of organism causing UTI, effect of gender & age on its prevalence, the antimicrobial susceptibility and resistance profile of bacterial isolates and compare it from national trend.
Method: Consecutive patient with culture positive UTI were enrolled in this study.
The urine samples were processed and microbial isolates were identified by conventional methods. Antimicrobial susceptibility testing was performed on all bacterial isolates by Kirby bauer’s disc diffusion method.
Result: 73 consecutive culture positive urinary sample from May 2017 to September 2018, was analysed. Most common organism isolated is E.coli (n=36) followed by klebseilla (n=11), staphylococcus aureus (n=11), enterococcus species(n=7), candida (n=7), proteus mirabilis (n=1).Most of the E. Coli was resistant to ceftriaxone followed by amoxicillin and maximum sensitivity seen with nitrofurantoin. Maximum resistance of klebsiella was seen with amoxicillin followed by ceftriaxone. None of the staphylococcus aureus isolated in this study was sensitive to amoxicillin and maximum resistance seen with cephalexin followed by cotrimoxazole and teicoplanin.
Discussion: most common organism causing UTI comes out to be E.coli and klebsiella which shows increasing resistant to ceftriaxone and amoxicillin in pediatric age group. This necessitates the need to form regional antibiogram to guide the therapy.
Keyword: UTI (urinary tract infection), E.coli, klebsiella, staphylococcus aureus, amoxicillin, ceftriaxone.
References
- Srivastava RN, Bagga A. Pediatric Nephrology: Urinary tract infection. 5th New Delhi; Jaypee brothers medical publishers (P) ltd, 2011. 273-294.
- KV Nisha, Rathika, D Shenoy, Veena Shetty, et al. Trends in antimicrobial resistance among uropathogens with special reference to Escherichia coli in community acquired Pediatric urinary tract infection from Kerela. J of Evolution of Med and Dent sci. 2015; volume 7: 9313-9319.
- Neelam T, Chattererjee SS, S Meenakshi, et al. 2010.Pediatric urinary tract infections in tertiary care center from north India. Indian J Med Res,101-104.
- Ghadage DP, Muley VA, J Sharma J, et al. 2016.Bacteriological profile and antibiogram of urinary tract infections at a tertiary care hospital. National journal of Lab med,5(4),20-24.
- Sharan R, Kumar D, Mukherjee B. Bacteriology and antibiotic resistance pattern in community acquired urinary tract infection. Indian pediatrics 2013;50:707
- Rao S, Rama PS, Gurushandapa V, et al. Extended-spectrum beta lactamases producing Escherichia Coli and Klebseilla pneumonia: A multi-centric study across Karnataka. J Lab physicians,6(1),7-13.
- Kothari A and Sagar V.2008.Antibiotic resistance in pathogens causing community-acquired urinary tract infections in India: A multicenter study,2(5),354-358.
- Dash M, Padhi S, Mohanty I,et al.2013.Antibiotic resistance in pathogens causing urinary tract infections in a rural community of odisha. J Family Community Med, 20(1), 20-26.
- American academy of pediatrics, subcommittee on urinary tract infections. Urinary tract infection: Clinical practice guideline for the diagnosis and management of initial UTI in febrile infants and young children 2 to 24 months. Pediatrics 2011;128:593-690.