Title: Serum Creatine Kinase Levels in Overt and Subclinical Hypothyroidism
Authors: Dr Vikas, Dr Gurdeep Kaur, Dr Neera Samar, Dr Avinash Kulkarni, Dr Sanjay Parmar, Dr Rohtash Gurjar
DOI: https://dx.doi.org/10.18535/jmscr/v6i10.136
Abstract
Introduction: Aim of present study is to assess the relationship between thyroid function and creatine kinase in patients with overt and subclinical hypothyroidism and correlation with thyroid hormone levels.
Methodology: The study consists of 30 control, 30 overt and 30 subclinical primary hypothyroidism patients with females(81%)>males (19%) attending medicine and endocrine outdoor in R.N.T. Medical college after taking oral informed consent and applying inclusion and exclusion criteria.
Observations: The study showed statistically significant increase in creatine kinase in overt hypothyroidism and subclinical hypothyroidism (172.77) compared to controls (97.60)
Conclusion: A highly positive correlation is observed between TSH and CK activity (p value <0.001) in the present study which indicates the influence of TSH on muscles in hypothyroidism though the rise of CK activity is nearly 4 to 5 times more in overt cases .There is highly significant negative correlation between T3 and T4 level with CK activity in the present study indicative of predominant role of decreased T3 and T4 level in overt cases in influencing this release of CK from skeletal muscles.
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