Abstract
Introduction: Pre-Eclampsia is a multi-system disorder of unknown aetiology, unique to pregnancy, onset after 20 weeks of gestation with hypertension to the extent of 140/90 mm Hg or more, and proteinuria (≥300mg/day) and edema. FOGSI (The Federation of Obstetric & Gynaecological Societies of India) and other studies show the incidence of Pre-Eclampsia in India ranges between 11-13%. And in North-East region of India it is very much common. NFHS has been conducted in India for three successive rounds. Among states highest prevalance found in Tripura (87.5%) and lowest prevalance state Haryana (33.3%). Lactate Dehydrogenase (LDH) is mainly an intracellular enzyme. It is responsible for interconversion of pyruvate and lactate in the cells. Its levels are several times greater inside the cells than in the plasma. LDH levels are increased in the scenario of increased cell leakiness, hemolysis and cell death. Pre-Eclampsia is a multisystem disorder and leads to a lot of cellular death. So, serum LDH levels can be used to assess the extent of cellular death and thereby the severity of disease. Uric Acid is a catabolic product of purine Nucleotide. Hyperuricemia is found to be one of the largest laboratory manifestations of Pre-Eclampsia. It is likely to be resulted from reduced Uric Acid clearance from reduced glomerular filtration rate and reduced tubular secretion. Hence, Serum LDH Levels and Uric Acid can be used as tool in making decision, regarding the management strategies to improve the maternal and fetal outcome.
Materials and Methods: The subjects for the study were divided into 3 groups:
Group I – Control groups = 60 normal pregnant women of >20weeks of gestation, age between 18 to 35 years.
Group II – Case group 1 = 30 newly diagnosed cases of Mild Pre-Eclampsia women of >20weeks of gestation, age between 18 to 35 years.
Group III – Case group 2 = 30 newly diagnosed cases of Severe Pre-Eclampsia women of >20weeks of gestation, age between 18 to 35 years.
Results: To compare Serum LDH levels in normal pregnant women and in women with Pre-Eclampsia. To compare Serum Uric Acid levels in normal pregnant woman and in woman with Pre- Eclampsia. To find out any possible correlation of their levels with the severity of the disease.
Conclusion: On the basis of our results we conclude the study that, there is a significant elevation of Serum LDH and Uric Acid in both Mild Pre-Eclampsia and Severe Pre-Eclampsia patients compared to normal pregnant women. Increased levels of Serum LDH and Uric Acid acts as efficient biomarkers for early diagnosis of Pre-Eclampsia and its subsequent course of the disease. So, Serum LDH Levels and Uric Acid can be used as tool in making decision, regarding the management strategies to improve the maternal and fetal outcome.
Keywords: Mild and Severe Pre-Eclampsia, LDH, Uric acid.
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Corresponding Author
Moumita Saha
MD Biochemistry, Dept of Biochemistry, Gauhati Medical College & Hospital, Guwahati, Assam, India
DOI: https://dx.doi.org/10.18535/jmscr/v6i8.205
