Abstract
Colorectal cancer is the third most common cancer worldwide. Surgery remains the primary determinant of cure in patients with localized rectal cancer and for patients with invasive tumors neo-adjuvant chemoradiotherapy has been utilized to promote tumor regression. EGFR, VEGF and p53 are among the markers currently of interest as potential predictors of pathologic response, prognosis and recurrence-free survival in rectal cancer. In this study we assess the prognostic value of p53, VEGF and EGFR and predictive value of these molecular markers in assessing the overall outcome in cases of carcinoma rectum. Biopsy proven patients of carcinoma rectum (stage I to stage IV) were included in the study. Patients were treated according to standard protocols. Patients were followed for response to CRT, disease free survival and overall outcome. Our study shows over expression of p53, VEGF and EGFR are associated with poor response from CRT, poor outcome and short survival in carcinoma rectum. These findings were statistically significant for VEGF and EGFR (not significant for p53).We conclude that study with larger sample size and longer follow up may establish these markers as independent predictor of overall outcome in patient of carcinoma rectum.
Keywords: Epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), p53, colorectal cancer (CRC) and chemoradiotherapy (CRT).
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Corresponding Author
Dr Arshad Ahmad
Associate Professor, Department of Surgery, King George’s Medical University, Lucknow, India-226003
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v6i8.02
