Abstract
POEMS Syndrome is a rare disorder with multiple entities constituting it and it commonly presents in the fifth to sixth decade of life with a male predominance. We report a case of a 79-year-old male from South India who initially presented with vague complaints of tiredness and weakness for the past few months along with thrombocytopenia. Further investigations led to the discovery of the presence of Monoclonal plasma cell disorder with M Band in the Beta 1 region, severe sensorimotor polyneuropathy and other findings which fulfilled the criteria for POEMS syndrome.
Keywords: POEMS Syndrome, Multiple Myeloma, Vitamin B12 deficiency.
References
- Dispenzieri A et al. POEMS syndrome: definitions and long-term outcome. Blood 2003; 101:2496.
- Gherardi RK et al. Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome. Blood 1996; 87:1458.
- Rajkumar SV et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 2014; 15:e538.
- Watanabe O et al. Overproduction of vascular endothelial growth factor/vascular permeability factor is causative in Crow-Fukase (POEMS) syndrome. Muscle Nerve 1998; 21:1390.
- Abe D et al. Restrictive usage of monoclonal immunoglobulin lambda light chain germline in POEMS syndrome. Blood 2008; 112:836.
- Mseddi-Hdiji S et al. Monoclonal gammapa-thies in Tunisia: epidemiol-ogical, immunochemical and etiological analysis of 288 Pathol Biol (Paris) 2005;53:19-25.
- Allam JS et al. Pulmonary manifestations in patients with POEMS syndrome: a retrospective review of 137 patients. Chest 2008; 133:969.
- Rose C et al. POEMS syndrome: report on six patients with unusual clinical signs, elevated levels of cytokines, macrophage involvement and chromosomal aberrations of bone marrow plasma cells. Leukemia 1997; 11:1318.
- He H et al. Successful treatment of newly diagnosed POEMS syndrome with reduced-dose bortezomib based regimen. Br J Haematol 2018; 181:126.
Corresponding Author
Dr S.R. Ramakrishnan
Address: 2/79, MGR Street, Srinivasapuram, Iyappanthangal, Chennai, Tamil Nadu, India 600056
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Phone: 9444912452
DOI: https://dx.doi.org/10.18535/jmscr/v6i7.185
